Study on the medication rule of traditional chinese medicine in treating chronic insomnia based on data mining
LIN Ling1 YUAN Jie2 LIU Dongling2 HAN Zucheng2 LUO Fan1 WANG Ying1 CHEN Jie2
1.The First Clinical College, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Department of Encephalopathy, Shaanxi Traditional Chinese Medicine Hospital, Shaanxi Province, Xi’an 710003, China
Abstract：Objective To summarize the drug rules of traditional Chinese medicine in treating chronic insomnia by data mining. Methods The literatures related to the treatment of chronic insomnia with traditional Chinese medicine from October 2010 to October 2020 were retrieved from CNKI, Wanfang, and VIP databases, the database was constructed by screening prescriptions, and mining was carried out by frequency analysis, association rules and cluster analysis. Results A total of 206 prescriptions were included, involving 193 traditional Chinese medicines. The top five drugs were Suanzaoren, Poria cocos, oyster, keel, and Polygala tenuifolia. The most commonly used categories of traditional Chinese medicine were tranquilizing drugs, deficiency-tonifying drugs, heat-clearing drugs and so on. The common dosage of the top 20 drugs were in accordance with the dosage stipulated in Chinese Pharmacopoeia and Internal Medicine of Traditional Chinese Medicine. The four qi of drug were mainly cold and flat, the five flavors were sweet and bitter, and the meridians were mainly the meridians of the heart, liver, and spleen. The combination of keel and oyster was the most used drug. Unearthed 16 core combinations, 8 new prescriptions by data mining. Conclusion Through excavation and analysis, it can be seen that the pathological factors of chronic insomnia are mainly deficiency, fire, phlegm, and heat. Traditional Chinese medicines such as tranquilizing the mind, tonifying deficiency, clearing away heat, resolving phlegm, and regulating qi are used in the treatment, which provide references for clinical drug use.
林玲1 袁捷2 刘冬玲2 韩祖成2 骆凡1 王莹1 陈杰2. 基于数据挖掘分析中药治疗慢性失眠的用药规律[J]. 中国医药导报, 2022, 19(31): 18-21.
LIN Ling1 YUAN Jie2 LIU Dongling2 HAN Zucheng2 LUO Fan1 WANG Ying1 CHEN Jie2. Study on the medication rule of traditional chinese medicine in treating chronic insomnia based on data mining. 中国医药导报, 2022, 19(31): 18-21.
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