Curative effect of Zoledronate combined with Diacerein on postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis
ZENG Li1 WANG Yongcai1 XING Gengyan2 YAN Bing1
1.Department of Joint Surgery, Leshan People’s Hospital, Sichuan Province, Leshan 614000, China;
2.Orthopaedic Center, the Third Medical Center of the Chinese People’s Liberation Army General Hospital, Beijing 100039, China
Abstract：Objective To study the curative effect of Zoledronate combined with Diacerein on postmenopausal osteoporosis complicated with early and middle knee osteoarthritis. Methods A total of 40 postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis patients in the Department of Joint Surgery, Leshan People’s Hospital of Sichuan Province were selected from December 2019 to December 2020. They were divided into experimental group and control group by random number table method, with 20 cases in each group. The control group was treated with Zoledronate and Caltrate, and the experimental group was treated with Diacerein on the basis of control group. The scores of Western Ontario and McMaster University osteoarthritis index (WOMAC), Lequesne, and visual analogue scale (VAS) were compared between two groups before treatment and 1, 6, and 12 months after treatment. Results There were significant differences in WOMAC score, Lequesne score, and VAS score between two groups at different time points (P < 0.05). At 1, 6, and 12 months of treatment, the scores of WOMAC and VAS of two groups were significantly different (P < 0.05); there was no significant difference in Lequesne score between two groups (P > 0.05). Conclusion Zoledronate combined with Diacerein can significantly relieve knee joint pain and improve knee joint function in the treatment of postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis.
曾立1 王永才1 邢更彦2 闫冰1. 唑来膦酸联合双醋瑞因对绝经后骨质疏松合并早中期膝骨关节炎疗效[J]. 中国医药导报, 2022, 19(30): 88-91.
ZENG Li1 WANG Yongcai1 XING Gengyan2 YAN Bing1. Curative effect of Zoledronate combined with Diacerein on postmenopausal osteoporosis complicated with early and middle stage knee osteoarthritis. 中国医药导报, 2022, 19(30): 88-91.
[1] Pek LT，Kim LB，Belinda L，et al. Patient experiences with physiotherapy for knee osteoarthritis in Australia-a qualitative study [J]. BMJ Open，2021，11（3）：e043689.
[2] Hong SG，Muhammad HR，Asnida AW，et al. From classical to deep learning：review on cartilage and bone segmentation techniques in knee osteoarthritis research [J]. Artif Intell Rev，2020，54（4）：2445-2494.
[3] Barbara S，Aleksandra T，Karin M，et al. Risk of knee osteoarthritis after different types of knee injuries in young adults：a population-based cohort study [J]. Br J Sports Med，2020，54（12）：725-730.
[4] 赵金芝.中老年膝骨关节炎发病病因及相关危险因素分析[J].山西医药杂志，2016，45（3）：250-252.
[5] Higgs R. Osteoarthritis：Concentrated efforts to detect early OA [J]. Nat Rev Rheumatol，2010，6（11）：616.
[6] Nikhil A，Christopher M，Christine B，et al. Meta-Analysis of Adipose Tissue Derived Cell-Based Therapy for the Treatment of Knee Osteoarthritis [J]. Cells，2021，10（6）：1-31.
[7] John WB，Matthew BA，Darby AH，et al. Platelet-Rich Plasma Versus Hyaluronic Acid for Knee Osteoarthritis：A Systematic Review and Meta-analysis of Randomized Controlled Trials [J]. Am J Sports Med，2021，49（1）：249-260.
[8] 吕永美，李承文.绝经后骨质疏松唑来膦酸及钙尔奇D治疗临床观察[J].中国骨质疏松杂志，2020，26（7）：1034-1038.
[9] 黄进贤，张会昌，尹志华，等.双醋瑞因、硫酸氨基葡萄糖联合璃酸钠治疗膝骨关节炎的疗效[J].实用医学杂志，2013，29（22）：3749-3751.
[10] Boileau C，Tat SK，Pelletier JP，et al. Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone：a possible mechanism for a protective effect against subchondral bone remodeling [J]. Arthritis Res Ther，2008，10（3）：R71.
[11] Pavelka K，Trc T，Karpas K，et al. The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee：a randomized，multicenter，double-blind，placebo- controlled study with primary end points at two months after the end of a three-month treatment period [J]. Arthritis Rheum，2007，56（12）：4055-4064.
[12] Dnatalie JC，Devyani M，David TF，et al. Measures of Knee Function： International Knee Documentation Committee（IKDC）Subjective Knee Evaluation Form，Knee Injury and Osteoarthritis Outcome Score（KOOS），Knee Injury and OsteoarthritisOutcome Score Physical Function Short Form （KOOS-PS），Knee Outcome SurveyActivities of Daily Living Scale （KOS-ADL），Lysholm Knee Scoring Scale，Oxford KneeScore （OKS），Western Ontario and McMaster Universities Osteoarthritis Index（WOMAC），Activity Rating Scale（ARS），and Tegner Activity Score （TAS）[J].Arthritis Care Res，2011，11（11）：S208-S228.
[13] Lecorney J，Verhoeven F，Chouk M，et al. Knee Osteoarthritis：Correlation between catastrophizing and Lequesne index in case of osteoarthritis of the knee：A prospective study [J]. Joint Bone Spine，2018，85（5）：605-607.
[14] Gillian AH，Samra M，Tetyana K，et al. Measures of Adult Pain Visual Analog Scale for Pain（VAS Pain），Numeric Rating Scale for Pain（NRS Pain），McGill Pain Questionnaire （MPQ），Short-Form McGill Pain Questionnaire（SF-MPQ），Chronic Pain Grade Scale（CPGS），Short Form-36 Bodily Pain Scale（SF-36 BPS），and Measure of Intermittent and Constant Osteoarthritis Pain （ICOAP）[J]. Arthritis Care Res（Hoboken），2011，11（63）：S240-S252.
[15] Dragan P，Vilim M，Eduard R，et al. Knee Osteoarthritis：A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations [J]. Genes，2020，11（8）：854.
[16] Maheshwer B，Evan MP，Katlynn P，et al. Regenerative Potential of Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis and Chondral Defects：A Systematic Review and Meta-analysis [J]. Arthroscopy，2021，37（1）：362-378.
[17] 黄永明，杨伟铭，苏海涛，等.唑来膦酸对绝经后骨质疏松性腰背痛作用效果分析[J].世界临床药物，2015，36（7）：487-489.
[18] 胡俊江，郝轶群，刘中国，等.阿仑膦酸钠治疗早期骨关节炎疗效观察[J].中国药物与临床，2018，18（21）：29-30.
[19] Alberto G，Ignacio D，Christopher R，et al. Two-year clinical outcomes of autologous microfragmented adipose tissue in elderly patients with knee osteoarthritis：a multi-centric，international study [J]. Int Orthop，2021，45（5）：1179-1188.
[20] Gianluca T，Serena MCG，Annalisa C，et al. Intra-Articular Injections in Knee Osteoarthritis：A Review of Literature [J]. J Funct Morphol Kinesiol，2021，6（1）：1-9.
[21] 冯激波，吴恙，倪东亮，等.唑来膦酸联合透明质酸钠治疗绝经后骨质疏松合并膝骨关节炎的临床效果分析[J].中华全科医学，2016，14（6）：928-930.
[22] Akamatsu Y，Mitsugi N，Taki N，et al. Relationship between low bone mineral density and varus deformity in postmenopausal women with knee osteoarthritis [J]. J Rheumatol，2009，36（3）：592-597.
[23] Nigel KA，Thomas AP，Raveendhara RB，et al. Non-surgical management of knee osteoarthritis：comparison of ESCEO and OARSI 2019 guidelines [J]. Nat Rev Rheumatol，2021，17（1）：59-66.
[24] Tim DM，jaskarndip C. Editorial Commentary：Injections for Knee Osteoarthritis：Doc，You Gotta Help Me! [J]. Arthr- oscopy，2021，37（4）：1288-1289.
[25] Dylan GW，Christy C，Symone MB，et al. Topical nonsteroidal anti-inflammatory drugs in the treatment of knee osteoarthritis：a systematic review and meta-analysis [J]. Phys Sportsmed，2021，49（4）：381-391.
[26] Ian RR，Jonathan RG，Kenneth WL，et al. Zoledronate [J]. Bone，2020，137：115390.
[27] Ian RR，Anne MH，Borislav M，et al. Effects of Zoledronate on Cancer，Cardiac Events，and Mortality in Osteopenic Older Women [J]. J Bone Miner Res，2020，35（1）：20-27.
[28] 宋宏伟.盐酸氨基葡萄糖联合唑来膦酸治疗绝经后骨质疏松合并膝骨关节炎的疗效[J].中慢性病学杂志，2020， 21（7）：1101-1105.
[29] 赵青，许建，代静.双醋瑞因结合玻璃酸钠治疗膝关节骨关节炎的临床效果[J].临床和实验医学杂志，2020， 19（2）：203-205.
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