动脉僵硬度增加的发生机制及评估方法的研究进展

doi:10.20047/j.issn1673-7210.2022.30.10

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摘要动脉僵硬度被公认能够作为评估心血管事件的独立因素。越来越多临床研究表明，动脉僵硬度的评估能够预测心血管疾病、神经退行性病变和慢性肾脏疾病的发生风险。然而，动脉僵硬度的改变经常被错误地等同于动脉硬化或动脉粥样硬化的发生，并且对其发病机制了解甚少，同时在应用评估方法时不知其原理与局限。因此，本文旨在综述动脉僵硬度增加的概念，阐述近些年研究者对动脉僵硬发生机制的研究进展，并评估动脉僵硬度方法的原理、局限及临床应用。

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	蔡子纯李纪明

关键词 ：动脉僵硬度, 脉搏波速度, 动脉粥样硬化

Abstract：Arterial stiffness is recognized as an independent factor for assessing cardiovascular events. A growing number of clinical studies have shown that the assessment of arterial stiffness can predict the risk of cardiovascular disease, neurodegenerative disease, and chronic kidney disease. However, changes in arterial stiffness are often mistakenly equated with the development of arteriosclerosis or atherosclerosis, and little is known about its pathogenesis, and its rationale and limitations are unknown when applying assessment methods. Therefore, this article aims to review the concept of increased arterial stiffness, describe the research progress of researchers on the mechanism of arterial stiffness in recent years, and evaluate the principles, limitations, and clinical applications of arterial stiffness methods.

Key words： Arterial stiffness Pulse wave velocity Atherosclerosis

基金资助:国家自然科学基金资助项目（81870296）。

通讯作者: 李纪明（1976.9-），男，医学博士，博士生导师，主任医师；研究方向：心力衰竭、高血压发生机制的分子研究。

作者简介: 蔡子纯（1996.10-），女，南京医科大学上海东方临床医学院2019级心内科专业在读硕士研究生；研究方向：非编码RNA与心血管疾病。

引用本文:

蔡子纯李纪明. 动脉僵硬度增加的发生机制及评估方法的研究进展[J]. 中国医药导报, 2022, 19(30): 50-53,57.
CAI Zichun LI Jiming. Research progress on the mechanism and assessment methods of increased arterial stiffness. 中国医药导报, 2022, 19(30): 50-53,57.

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https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2022.30.10 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I30/50

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