Discussion on the biological connotation of “earth stagnation and wood constraint” in metabolic associated fatty liver disease based on “intestinal microbiota-bile acid interaction”
YAN Haiyi1 GUO Rui2 GUO Peng1#br#
1.Department of Hepatology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100029, China;
2.Center of Preventive Treatment of Disease, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100029, China
Abstract：Traditional Chinese medicine believes that “earth stagnation and wood constraint” is the main pathogenesis of metabolic associated fatty liver disease. Combined with the pathogenesis theory of traditional Chinese medicine and modern medical research, it is found that the dysregulation of intestinal microbiota is very likely to be an important biological basis of “earth stagnation” (dysfunction of spleen in transportation), and the imbalance of bile acid metabolism may be the microscopic manifestation of “wood constraint” (dysfunction of liver in conveyance and dispersion). The occurrence and development of metabolic associated fatty liver disease caused by the imbalance of “intestinal microbiota-bile acid interaction” from the perspective of western medicine is consistent with the main pathogenesis of “earth stagnation and wood constraint” from the perspective of traditional Chinese medicine. Based on the interaction between intestinal microbiota and bile acids, this paper preliminarily explores the biological connotation of the pathogenesis of “earth stagnation and wood constraint” in metabolic associated fatty liver disease, to provide new ideas for studying the pathogenesis of “earth stagnation and wood constraint” and promoting the prevention and treatment of metabolic associated fatty liver disease with traditional Chinese medicine。
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