Abstract：Chronic pain is one of the diseases that have the greatest negative impact on people’s quality of life in the world, and brings huge economic burden to society. The drug methods for treating chronic pain are limited and ineffective. Long non-coding RNA (lncRNA) is a class of non-coding RNA with sequence length more than 200 nucleotides and lack of protein-coding potential, but it plays an extensive and important biological regulatory role in vivo. Recent studies have found that lncRNA expression is dysregulated in a variety of chronic pain models, and it plays an important role in the development of chronic pain by affecting the function of various micrornas, inflammatory cytokines and ion channel activation. In this paper, lncRNA related studies involved in neuropathic pain, chronic inflammatory pain and bone cancer pain in recent years are analyzed and summarized, so as to discover valuable therapeutic targets and lay a theoretical foundation for the development of more effective analgesics.
余剑芒 杭黎华. 长链非编码RNA与慢性疼痛的相关研究进展[J]. 中国医药导报, 2022, 19(28): 59-62.
YU Jianmang HANG Lihua. Research advance of long non-coding RNA and chronic pain. 中国医药导报, 2022, 19(28): 59-62.
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