Abstract：Ferroptosis is a novel kind of cell death which is induced by the accumulation of iron-dependent lipid peroxidation. It has been proved ferroptosis modulates the tumorigenesis and tumor progression. Tumor infiltrating immune cells are critical components of tumor microenvironment. By modulating immune response, tumor infiltrating immune cells regulate tumor development and affect immunotherapy response. Previous studies indicate ferroptosis affects tumor infiltrating immune cell function to modulate tumor progression. This review introduces the molecular mechanism of ferroptosis and summarizes the regulatory role of ferroptosis in tumor infiltrating immune cells, which is expected to provide new strategy to improve immunotherapy efficacy.
王榕林 马珮翔 花蕾 杨成 郭永东 李俊强 苏海川. 铁死亡在肿瘤浸润淋巴细胞中的作用研究进展[J]. 中国医药导报, 2022, 19(28): 50-53.
WANG Ronglin MA Peixiang HUA Lei YANG Cheng GUO Yongdong LI Junqiang SU Haichuan. Research progress of ferroptosis function in the tumor-infiltrating lymphocyte. 中国医药导报, 2022, 19(28): 50-53.
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