Predictive value of nasal polyps tissues’ eosinophilic cationic protein/myeloperoxidase, chemokine ligand 4, and immunoglobulin E in the recurrence of patients with chronic rhinosinusitis with nasal polyps after surgery
LIN Qiuhong XIAO Xiang ZHANG Shujia HAN Jiahui DONG Chunguang▲#br#
Department of Otolaryngology and Head and Neck Surgery, the First People’s Hospital of Lianyungang City, Jiangsu Province, Lianyungang 222000, China
Abstract：Objective To investigate the predictive value of nasal polyps tissues’ eosinophilic cationic protein (ECP)/myeloperoxidase (MPO), chemokine ligand 4 (CCL4), and immunoglobulin E (IgE) in the recurrence of patients with chronic rhinosinusitis with nasal polyps (CRSwNP) after surgery. Methods A total of 189 patients with CRSwNP who underwent endoscopic nasal surgery in the First People’s Hospital of Lianyungang City, Jiangsu Province from January 2017 to December 2019 were selected as the research objects. According to the recurrence within two years after surgery, they were divided into recurrence group (26 cases) and non-recurrence group (163 cases). The clinical data and the levels of ECP/MPO, CCL4, and IgE in nasal polyps tissues were compared between the two groups, and the influencing factors of CRSwNP recurrence and the clinical value of ECP/MPO, CCL4, and IgE levels in CRSwNP recurrence were further analyzed. Results The nasal polyps Davos score, the proportion of smoking history, the proportion of postoperative infection, and the levels of ECP/MPO, CCL4, and IgE in the recurrence group were higher than those in the non-recurrence group, and the differences were statistically significant (P ＜ 0.05). The results of multivariate analysis showed that smoking, postoperative infection, ECP/MPO, CCL4, and IgE were the influencing factors of recurrence in patients with CRSwNP within two years after surgery (P ＜ 0.05). ECP/MPO, CCL4, and IgE levels alone and in combination had certain predictive value for recurrence in patients with CRSwNP within two years after surgery (area under the curve > 0.5, P < 0.05). Conclusion ECP/MPO, CCL4, and IgE in nasal polyps tissues alone and in combination have clinical value in predicting CRSwNP recurrence within two years after surgery, which is worthy of further analysis and discussion.
林秋红 肖祥 张书嘉 韩加辉 董春光▲. 鼻息肉组织中嗜酸性阳离子蛋白/髓过氧化物酶、趋化因子配体4、免疫球蛋白E对慢性鼻窦炎伴鼻息肉术后复发的预测价值[J]. 中国医药导报, 2022, 19(27): 106-109,118.
LIN Qiuhong XIAO Xiang ZHANG Shujia HAN Jiahui DONG Chunguang▲. Predictive value of nasal polyps tissues’ eosinophilic cationic protein/myeloperoxidase, chemokine ligand 4, and immunoglobulin E in the recurrence of patients with chronic rhinosinusitis with nasal polyps after surgery. 中国医药导报, 2022, 19(27): 106-109,118.
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