长链非编码RNA在急性肾损伤中的研究进展

doi:10.20047/j.issn1673-7210.2022.27.10

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摘要急性肾损伤（AKI)表现为短时间内肾功能快速丧失，脓毒症、缺血再灌注、肾毒性物质是其主要病因。AKI机制尚不明确且缺乏有效的诊断、治疗方法。随着新型测序技术发展，越来越多的长链非编码RNAs（lncRNAs）在AKI患者及动物和细胞模型中被检测到异常表达。研究表明，lncRNA可能通过海绵吸附miRNA靶向调控炎症、氧化和凋亡等信号通路，在AKI的发生、发展和预后中起到重要的作用。本文就lncRNA在AKI中的作用机制及潜在应用进行综述。

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	谢安妮余燕婷王晓燕

关键词 ：长链非编码RNA, 急性肾损伤, 生物标志物, 脓毒症, 缺血再灌注

Abstract：Acute kidney injury (AKI) is characterized by rapid loss of renal function in a short period of time. Sepsis, ischemia-reperfusion, and nephrotoxic substances are the main causes of AKI. The mechanism of AKI is still unclear and there is a lack of effective diagnosis and treatment. With the novel development of sequencing technology, more and more long non-coding RNAs (lncRNAs) have been identified to abnormally expressed in AKI patients and animal and cell models. Studies have shown that lncRNA may play an important role in the occurrence, development, and prognosis of AKI by targeting inflammation, oxidation, and apoptosis signaling pathways through sponge adsorption of miRNA. This article reviews the mechanism and potential application of lncRNA in AKI.

Key words： Long non-coding RNA Acute kidney injury Biomarker Sepsis Ischemia-reperfusion

基金资助:国家自然科学基金资助项目（81970605、81900650）。

通讯作者: 王晓燕（1961.4-），女，博士，教授，南京医科大学附属明基医院中心实验室主任，主要从事肾脏病相关研究。余燕婷（1984.2-），女，博士，副教授，南京医科大学附属明基医院肾脏内科副主任，主要从事肾脏病相关研究。

引用本文:

谢安妮余燕婷王晓燕. 长链非编码RNA在急性肾损伤中的研究进展[J]. 中国医药导报, 2022, 19(27): 47-49.
XIE Anni YU Yanting WANG Xiaoyan. Research progress of long non-coding RNA in acute kidney injury. 中国医药导报, 2022, 19(27): 47-49.

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