Meta analysis of the relationship between L-type amino acid transporter 1 and solid tumor metastasis
WU Sihui1 ZHOU Xulin1 HUANG Wenkang1 XU Min2
1.The First Clinical Medical College, Jiangsu University, Jiangsu Province, Zhenjiang 212000, China;
2.Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu Province, Zhenjiang 212000, China
Abstract：Objective To investigate the correlation between L-type amino acid transporter 1(LAT1) and solid tumor metastasis. Methods Medline/PubMed, Embase, EBSCO, The Cochrane Library, Springerlink, Web of Science core collectior databas, Wiley Onlinelibary, China National Knowledge Infrastructure, and Cochrane Center for Controlled Clinical Trials (Cochrane) were used for literature search, two authors independently screened the literature, extracted data, and grouped the final materials Patients were divided into groups according to the relevant indexes to be studied, including lymph node metastasis positive group and negative group, lymphatic vessel invasion positive group and negative group, vascular invasion positive group and negative group. Patients with high LAT1 expression were screened out from each group for data analysis, and the differences between groups were compared. The literature search date was from the establishment of the database to May 2021, and the final meta analysis was performed using RevMan 5.4 software. Results After screening, 15 literatures were included. LAT1 expression was a risk factor for lymph node metastasis of most tumors, and there was a significant relationship between LAT1 expression and lymph node metastasis (OR = 2.03, 95%CI:1.44-2.86, P < 0.000 1). LAT1 expression was a significant risk factor for vascular invasion of most tumors (OR = 2.92, 95%CI:2.16-3.96, P < 0.000 01). Conclusion The expression of LAT1 is correlated with lymph node metastasis and vascular invasion, LAT1 is one of the promoting factors for metastasis of various solid tumors.
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