心率变异性与脑小血管病磁共振成像总负荷的相关性分析

doi:10.20047/j.issn1673-7210.2022.26.19

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摘要目的分析心率变异性（HRV）与脑小血管病（CSVD）磁共振成像（MRI）总负荷的相关性。方法以2019年1月至2021年6月郑州大学第二附属医院神经内科收治的188例CSVD患者为研究对象，根据腔隙、微出血、白质高信号及血管周围间隙的影像学结果对其进行总负荷评分，0～2分纳入低负荷组（132例），3～4分纳入高负荷组（56例）。比较两组一般资料、HRV参数和影像学相关指标，并进一步分析HRV参数与MRI总负荷评分的相关性，以及CSVD患者MRI总负荷评分的影响因素。结果高负荷组年龄高于低负荷组，24 h平均心率、全部NN区间的标准差（SDNN）、全部NN区间每5分钟时间段的平均值的标准差（SDANN）、全程相邻NN间期之差的均方根值（rMSSD）、总功率（TP）、低频功率（LF）、LF/高频功率（HF）均低于低负荷组，差异有统计学意义（P ＜ 0.05）。SDNN、SDANN、rMSSD、TP、LF、LF/HF与CSVD患者MRI总负荷评分呈负相关（rs ＜ 0，P ＜ 0.05）。多因素分析结果显示，rMSSD是CSVD患者MRI总负荷评分的影响因素（P ＜ 0.05）。结论 HRV参数与CSVD患者MRI总负荷评分相关，自主神经功能紊乱可能与CSVD的发生发展相关。

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	刘月臣徐辉白宏英▲

关键词 ：脑小血管病, 总负荷, 心率变异性, 影像学

Abstract：Objective To analyze the correlation between heart rate variability (HRV) and the total load of magnetic resonance imaging (MRI) in cerebral small vessel disease (CSVD). Methods A total of 188 patients with CSVD admitted to the Department of Neurology, the Second Affiliated Hospital of Zhengzhou University from January 2019 to June 2021 were selected as the research objects. According to the imaging results of lacunae, microbleeds, white matter hyperintensity, and perivascular space, the total load score was evaluated. The score of 0-2 points was included in the low load group (132 cases), and the score of 3-4 points was included in the high load group (56 cases). The general data, HRV parameters, and imaging related indexes of the two groups were compared, and the correlation between HRV parameters and MRI total load score, as well as the influencing factors of MRI total load score in CSVD patients were further analyzed. Results The age of the high load group was higher than that of the low load group, the 24 h mean heart rate, standard deviation of the N-N intervals (SDNN), standard deviation of the averages of N-N intervals in all five minute segments of the entire recording (SDANN), root mean square value of the difference between adjacent N-N intervals (rMSSD), total power (TP), low frequency power (LF), and LF/high frequency power (HF) were all lower than those of the low load group, the differences were statistically significant (P ＜ 0.05). SDNN, SDANN, rMSSD, TP, LF, LF/HF were negatively correlated with the total MRI load score of CSVD patients (rs ＜ 0, P ＜ 0.05). Multivariate analysis showed that rMSSD were the influencing factors of MRI total load score of CSVD (P ＜ 0.05). Conclusion HRV parameters are correlated with the MRI total load score of CSVD patients, and autonomic nervous dysfunction may be related to the development of CSVD.

Key words： Cerebral small vessel disease Total load Heart rate variability Imaging

基金资助:河南省医学科技攻关计划（联合共建）项目（LHGJ20190314）。

通讯作者: ▲通讯作者

引用本文:

刘月臣徐辉白宏英▲. 心率变异性与脑小血管病磁共振成像总负荷的相关性分析[J]. 中国医药导报, 2022, 19(26): 86-89,98.
LIU Yuechen XU Hui BAI Hongying▲. Analysis on the correlation between heart rate variability and total load of magnetic resonance imaging in cerebral small vessel disease. 中国医药导报, 2022, 19(26): 86-89,98.

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