Abstract：Objective To investigate the research status, hotspots, and future trends of olfactory ensheathing cells transplantation in the treatment of spinal cord injury in the past 20 years. Methods Literatures published in 1999 to 2021 were retrieved in the core collection of Web of Science with the subject words “spinal injur *” and “OEC” or “OECs”, bibliometric analysis and visual analysis were carried out based on CiteSpace. Results A total of 370 articles were included, including 324 works. From 2002 to 2013, the number of published papers showed an increasing trend year by year, and then the annual number of published papers remained stable in the region. CELL TRANSPLANTATION, EXPERIMENTAL NEUROLOGY, and GLIA were the top three journals with the largest number of publications. St John JA, Griffith University, and China ranked first in terms of authors, institutions, and countries respectively. Keywords are Schwann cells, functional repair, in vitro, transplantation, glia, regeneration, axonal regeneration, etc. Conclusion CiteSpace software is used to visually analyze the relevant literature on olfactory ensheathing cells transplantation in the treatment of spinal cord injury, to show the current research status and hot spots in this field, and to provide certain data reference for scholars in related fields in the future.
[1] Rowland JW，Hawryluk GWJ，Kwon B，et al. Current status of acute spinal cord injury pathophysiology and emerging therapies：promise on the horizon [J]. Neurosurg Focus，2008，25（5）：E2.
[2] Tysseling-Mattiace VM，Sahni V，Niece KL，et al. Self-assembling nanofibers inhibit glial scar formation and promote axon elongation after spinal cord injury [J]. J Neurosci，2008，28（14）：3814-3823.
[3] 李嘉熙，高正超，贺西京，等.嗅鞘细胞治疗脊髓损伤的研究进展[J].中国骨伤，2021，34（8）：785-790.
[4] Kim U，De Vellis J. Stem Cell-Based Cell Therapy in Neurological Diseases：A Review [J]. J Neurosci Res，2009， 87（10）：2183-2200.
[5] Chen CM，Hu ZG，Liu SB，et al. Emerging trends in regenerative medicine：a scientometric analysis in CiteSpace [J]. Expert Opin Biol Th，2012，12（5）：593-608.
[6] Surrao DC，Arasu Y，Ekberg JAK，et al. Blended，crosslinked alginate-methylcellulose hydrogels for encapsulation and delivery of olfactory ensheathing cells [J]. Materialia，2020， 10：100654.
[7] Ye LP，Zhang XP. Visualizing the knowledge structure of medication-adherence research：A bibliometric analysis （1997-2016） [J]. Int J Health Plan M，2019，34（4）：1333-1353.
[8] Munoz-Quiles C，Santos-Benito FF，Liamusi MB，et al. Chronic Spinal Injury Repair by Olfactory Bulb Ensheathing Glia and Feasibility for Autologous Therapy [J]. J Neuropath Exp Neur，2009，68（12）：1294-1308.
[9] Chung RS，Woodhouse A，Fung S，et al. Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors [J]. Cell Mol Life Sci，2004，61（10）：1238-1245.
[10] Huang HY，Chen L，Mao GS，et al. The 2019 yearbook of Neurorestoratology [J]. J Neurorestoratology，2020，8（1）：1-11.
[11] Zhang L，Zhuang X，Chen Y，et al. Intravenous transplantation of olfactory bulb ensheathing cells for a spinal cord hemisection injury rat model [J]. Cell Transplant，2019，28（12）：1585-1602.
[12] Khankan RR，Wanner IB，Phelps PE. Olfactory ensheathing cell-neurite alignment enhances neurite outgrowth in scar-like cultures [J]. Exp Neurol，2015，269：93-101.
[13] Thornton MA，Mehta MD，Morad TT，et al. Evidence of axon connectivity across a spinal cord transection in rats treated with epidural stimulation and motor training combined with olfactory updates ensheathing cell transplantation [J]. Experiment Neurol，2018，309：119-133.
[14] Xie J，Huo S，Li Y，et al. Olfactory Ensheathing Cells Inhibit Gliosis in Retinal Degeneration by Downregulation of the Muller Cell Notch Signaling Pathway [J]. Cell Transplant，2017，26（6）：967-982.
[15] Liadi M，Collins A，Li Y，et al. The Impact of Tissue Storage Conditions on Rat Olfactory Ensheathing Cell Yield and the Future Clinical Implications [J]. Cell Transplant，2018，27（9）：1320-1327.
[16] Reshamwala R，Shah M，St John J，et al. Survival and Integration of Transplanted Olfactory Ensheathing Cells are Crucial for Spinal Cord Injury Repair：Insights from the Last 10 Years of Animal Model Studies [J]. Cell Transplant，2019，28（1_suppl）：132S-159S.
[17] Ramon-Cueto A，Cordero MI，Santos-Benito FF，et al. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia [J]. Neuron，2000，25（2）：425-435.
[18] Lopez-Vales R，Fores J，Navarro X，et al. Chronic transplantation of olfactory ensheathing cells promotes partial recovery after complete spinal cord transection in the rat [J]. Glia，2007，55（3）：303-311.
[19] Su Z，He C. Olfactory ensheathing cells：biology in neural development and regeneration [J]. Prog Neurobiol，2010， 92（4）：517-532.
[20] Zhao Y，Tang F，Xiao Z，et al. Clinical Study of NeuroRegen Scaffold Combined With Human Mesenchymal Stem Cells for the Repair of Chronic Complete Spinal Cord Injury [J]. Cell Transplant，2017，26（5）：891-900.
[21] Wang GY，Cheng ZJ，Yuan PW，et al. Olfactory ensheathing cell transplantation alters the expression of chondroitin sulfate proteoglycans and promotes axonal regeneration after spinal cord injury [J]. Neural Regen Res，2021，16（8）：1638-1644.
[22] Wright AA，Todorovic M，Tello-Velasquez J，et al. Enhancing the Therapeutic Potential of Olfactory Ensheathing Cells in Spinal Cord Repair Using Neurotrophins [J]. Cell Transplant，2018，27（6）：867-878.
[23] Wang Y，Teng HL，Gao Y，et al. Brain-derived Neurotrophic Factor Promotes the Migration of Olfactory Ensheathing Cells Through TRPC Channels [J]. Glia，2016，64（12）：2154-2165.
[24] Li Y，Huo S，Fang Y，et al. ROCK Inhibitor Y27632 Induced Morphological Shift and Enhanced Neurite Outgrowth-Promoting Property of Olfactory Ensheathing Cells via YAP-Dependent Up-Regulation of L1-CAM [J]. Front Cell Neurosci，2018，12：489.
[25] Gao ZC，Zhao YJ，He XJ，et al. Transplantation of sh-miR-199a-5p-Modified Olfactory Ensheathing Cells Promotes the Functional Recovery in Rats with Contusive Spinal Cord Injury [J]. Cell Transplant，2020，29：963689 720916173.
京公网安备 11010502046598号