Research progress on antibiotic resistance of pathogenic Escherichia coli
REN Chenyin1 FU Yixiu2▲#br#
1.School of Clinical Medicine, Hangzhou Medical College, Zhejiang Province, Hangzhou 310053, China;
2.School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Zhejiang Province, Hangzhou 310053, China
Abstract：Pathogenic Escherichia coli can infect important tissues and organs through various infection routes in clinical practice. The irregular use of antibiotics leads to the accumulation and spread of bacterial resistance. Recent studies have shown that antibiotic resistance of pathogenic Escherichia coli is becoming increasingly severe. This article discusses the current status of drug resistance of common pathogenic Escherichia coli in clinical practice, and summarizes the drug resistance mechanisms of pathogenic Escherichia coli from the aspects of mobile genetic elements, target mutation and modification, and inactivated enzymes, explore the genetic engineering or molecular biology, Chinese medicine and some other novel non-antibiotic therapy methods, in order to provide reference information for alleviating the drug resistance of pathogenic Escherichia coli.
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