外泌体在重要脏器缺血再灌注损伤中的治疗作用研究进展

doi:10.20047/j.issn1673-7210.2022.25.07

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摘要缺血再灌注损伤（IRI）是一个从潜在危险因素到明显临床疾病的多步链式过程。血管细胞、血细胞、心肌细胞和干细胞都通过持续且多元的串扰参与病理生理环节。外泌体作为强大的细胞间通讯载体，一直是基础和临床研究的热点。大量证据表明，外泌体在很大程度上参与了IRI的演变，但其在实际治疗应用上仍存在争议，且临床对外泌体在疾病不同阶段的细胞间通讯功能中所扮演的角色仍然知之甚少。本文将就外泌体应用于重要脏器IRI的最新研究作一综述，重点讨论其靶向修饰的临床应用前景。

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	曾可君1 杨煜辉1 胡喆2▲

关键词 ：外泌体, 缺血再灌注损伤, 器官损伤与保护, 靶向治疗

Abstract：Ischemia reperfusion injury (IRI) is a multi-step chain process from potential risk factors to obvious clinical diseases. Vascular cells, blood cells, cardiomyocytes, and stem cells all participate in pathophysiology through continuous and multiple crosstalk. As a powerful carrier of cell-cell communication, exosomes has always been the focus of basic and clinical research. A large amount of evidence shows that exosomes are involved in the evolution of IRI to a large extent, but their actual therapeutical effect is still controversial. The clinical role of exosomes in cell-cell communication at different stages of disease is still poorly understood. This article reviews the latest research on the application of exosomes in IRI of important organs, and focus on the clinical application prospect of their targeted modification.

Key words： Exosomes Ischemia-reperfusion Organ injury and protection Targeted therapy

基金资助:国家自然科学基金资助项目（81870222）。

通讯作者: ▲通讯作者

作者简介: 曾可君（1995-），女，广东医科大学第一临床医学院2019级麻醉学专业在读硕士研究生；研究方向：缺血再灌注与器官保护。

引用本文:

曾可君1 杨煜辉1 胡喆2▲. 外泌体在重要脏器缺血再灌注损伤中的治疗作用研究进展[J]. 中国医药导报, 2022, 19(25): 33-37.
ZENG Kejun1 YANG Yuhui1 HU Zhe2▲. Research progress on the therapeutical effect of exosomes in ischemia reperfusion injury in important organs. 中国医药导报, 2022, 19(25): 33-37.

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