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升陷汤对肺癌化疗所致肺脾气虚型癌因性疲乏患者生活质量和免疫功能的影响
姜翠红1      吕雨桐1      赵志正2
1.中国中医科学院广安门医院南区肿瘤科,北京   102600;
2.中国中医科学院广安门医院肿瘤科,北京   100053
Effect of Shengxian Decoction on quality of life and immune function in patients with cancer-related fatigue of lung cancer caused by lung-spleen qi deficiency chemotherapy
JIANG Cuihong1   LYU Yutong1   ZHAO Zhizheng2
1.Department of Oncology, Southern District of Guang’anmen Hospital of Chinese Academy of Chinese Medical Sciences, Beijing   102600, China; 2.Department of Oncology, Guang’anmen Hospital of Chinese Academy of Chinese Medical Sciences, Beijing   100053, China
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摘要 目的 探讨升陷汤对肺癌化疗所致肺脾气虚型癌因性疲乏患者生活质量和免疫功能的影响。 方法 选取2018年5月至2022年2月中国中医科学院广安门医院南区收治的肺癌化疗所致癌因性疲乏患者102例,根据随机数字表法将其分为对照组和联合组,各51例。对照组给予白蛋白紫杉醇+铂类,联合组在此基础上使用升陷汤联合治疗。比较两组癌因性疲乏程度,对两组治疗前后肺功能、生活质量、免疫功能进行比较,观察两组毒副作用,比较两组治疗依从性情况。 结果 治疗后,联合组癌因性疲乏程度改善情况优于对照组(P < 0.05)。治疗后,两组第1秒用力呼气容积、用力肺活量比值、最大峰值呼气流速高于治疗前,且联合组高于对照组(P < 0.05);两组生活质量评分高于治疗前,且联合组高于对照组(P < 0.05);两组CD3+、CD4+、CD4+/CD8+均高于治疗前,且联合组高于对照组(P < 0.05);联合组治疗依从性优于对照组(P < 0.05);联合组毒副作用发生率低于对照组(P < 0.05)。结论 升陷汤可提高肺癌化疗所致癌因性疲乏患者生活质量,改善患者免疫功能及癌因性疲乏程度,毒副作用少,依从性高,值得临床进一步推广。
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姜翠红1 吕雨桐1 赵志正2
关键词 升陷汤肺癌癌因性疲乏生活质量免疫功能    
Abstract:Objective To investigate the effect of Shengxin Decoction on quality of life and immune function in patients with cancer-related fatigue of lung cancer caused by lung-spleen qi deficiency chemotherapy. Methods A total of 102 patients with oncogenic fatigue admitted to the Southern District of Guang’anmen Hospital of Chinese Academy of Chinese Medical Sciences from May 2018 to February 2022 were selected, according to the random number table method, they were divided into control group and combined group, with 51 cases in each group. The control group was given albumin Paclitaxel + Platinum, on this basis, the combined group was treated with Shengxian Decoction. The degree of cancer-related fatigue were compared between the two groups, the pulmonary function, quality of life and immune function of the two groups were compared before and after treatment, and the side effects of the two groups were observed, and the treatment compliance of the two groups was compared. Results After treatment, the improvement of cancer-related fatigue in the combined group was better than that in the control group (P < 0.05). After treatment, forced expiratory volume in one second, forced vital capacity ratio and maximum peak expiratory flow rate in the two group were higher than those before treatment, and those in the combined group were higher than those in the control group (P < 0.05); the scores of quality of life in the two group were higher than those before treatment, and the combined group was higher than that in the control group (P < 0.05). CD3+, CD4+, and CD4+/CD8+ in the two group were higher than those before treatment, and those in the combined group were higher than those in the control group (P < 0.05). The treatment compliance of the combined group was better than that of the control group (P < 0.05). The incidence of side effects in combination group was lower than that in control group (P < 0.05). Conclusion Shengxian Decoction can improve the quality of life of patients with oncogenic fatigue in lung cancer chemotherapy, improve the immune function and degree of cancer-related fatigue, and with less toxic side effects, high compliance, which is worthy of further clinical promotion.
Key wordsShengxian Decoction    Lung cancer    Cancer-related fatigue    Quality of life    Immune function
    
基金资助:国家自然科学基金资助项目(81703918);
中国中医科学院广安门医院南区院级科研基金课题(Y2019-04)。
通讯作者: 吕雨桐(1985-),女,硕士;研究方向:中医药治疗恶性肿瘤。   
作者简介: 姜翠红(1985-),女,硕士;研究方向:中医药治疗恶性肿瘤。
引用本文:   
姜翠红1 吕雨桐1 赵志正2. 升陷汤对肺癌化疗所致肺脾气虚型癌因性疲乏患者生活质量和免疫功能的影响[J]. 中国医药导报, 2022, 19(25): 10-14.
JIANG Cuihong1 LYU Yutong1 ZHAO Zhizheng2. Effect of Shengxian Decoction on quality of life and immune function in patients with cancer-related fatigue of lung cancer caused by lung-spleen qi deficiency chemotherapy. 中国医药导报, 2022, 19(25): 10-14.
链接本文:  
https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2022.25.02     或     https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I25/10

 

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