Clinical effect of the ointment of modified Shuyu Pills adjunctive treatnent of iron deficiency anemia
MA Xihu LIU Xiao HUANG Zhihui
Department of Hematology, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830000, China
Abstract:Objective To study the clinical effect of the ointment of modified Shuyu Pills adjunctive treatnent of iron deficiency anemia (IDA). Methods A total of 67 IDA patients in Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University from December 2018 to December 2021 were selected and they were divided into routine group (33 cases) and study group (34 cases) according to random number table method. The conventional group was treated with Polysaccharide Iron Compound Capsules, and the research group was treated with the ointment of modified Shuyu Pills adjuvant therapy. The curative effect was compared between the two groups after eight weeks of treatment, traditional Chinese medicine syndrome scores and blood indicators (hemoglobin [Hb], red blood cell count [RBC], serum ferritin [SF], total iron-binding capacity [TIBC]) were compared before and after eight weeks of treatment, and adverse reactions during treatment were counted. Results The clinical efficacy of the study group was better than that of the conventional group (P < 0.05). After eight weeks of treatment, the traditional Chinese medicine syndrome score was lower than that before treatment, and the study group was lower than that of the conventional group (P < 0.05). After eight weeks of treatment, Hb, RBC, and SF were higher than those before treatment, and the study group were higher than those in the conventional group (P < 0.05). After eight weeks of treatment, TIBC was lower than that before treatment, and the study group was lower than that of the conventional group (P < 0.05). The incidence of adverse reaction in the study group was lower than that in the conventional group (P < 0.05). Conclusion The effect of the ointment of modified Shuyu Pills adjunctive treatment of IDA is significant, which can reduce traditional Chinese medicine syndrome score, improve blood index and reduce the occurrence of adverse reactions.
马西虎 刘晓 黄志惠. 薯蓣丸加味制膏辅助治疗缺铁性贫血的临床效果[J]. 中国医药导报, 2022, 19(24): 128-131.
MA Xihu LIU Xiao HUANG Zhihui. Clinical effect of the ointment of modified Shuyu Pills adjunctive treatnent of iron deficiency anemia. 中国医药导报, 2022, 19(24): 128-131.
[1] Means RT. Iron Deficiency and Iron Deficiency Anemia:Implications and Impact in Pregnancy,Fetal Development,and Early Childhood Parameters [J]. Nutrients,2020, 12(2):447.
[2] Bellakhal S,Ouertani S,Antit S,et al. Iron deficiency anemia:clinical and etiological features [J]. Tunis Med,2019,97(12):1389-1398.
[3] Elstrott B,Khan L,Olson S,et al. The role of iron repletion in adult iron deficiency anemia and other diseases[J]. Eur J Haematol,2020,104(3):153-161.
[4] 杨辰,周道斌.缺铁性贫血的诊治及铁剂发展历程[J].临床药物治疗杂志,2021,19(8):18-22.
[5] 陈哲,段琴青,牧莹,等.益中生血片联合琥珀酸亚铁片治疗重度缺铁性贫血的临床研究[J].药物评价研究,2021, 44(4):780-784.
[6] 陈艳,陈国策,李瑞珍.健脾生血颗粒防治婴幼儿铁缺乏及缺铁性贫血的疗效观察[J].世界中医药,2020,15(14):2122-2126.
[7] 黎金庆,丛龙皎,黎牧郴,等.健脾生血片治疗缺铁性贫血临床效果的回顾性分析[J].世界中医药,2021,16(8):1268-1273.
[8] 中华医学会血液学分会红细胞疾病(贫血)学组.铁缺乏症和缺铁性贫血诊治和预防多学科专家共识[J].中华医学杂志,2018,98(28):2233-2237.
[9] 沈悌,赵永强.血液疾病诊断与疗效标准[M].4版.北京:科学出版社,2018:8-42.
[10] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:105-110.
[11] Sundararajan S,Rabe H. Prevention of iron deficiency anemia in infants and toddlers[J]. Pediatr Res,2021,89(1):63-73.
[12] Gómez-Ramírez S,Bisbe E,Shander A,et al. Management of Perioperative Iron Deficiency Anemia[J]. Acta Haematol,2019,142(1):21-29.
[13] 陈晓哲,李亚琴,赵文聪.生血宁片联合琥珀酸亚铁片对妊娠期缺铁性贫血患者铁代谢、免疫功能的影响[J].临床医学研究与实践,2021,6(17):117-119.
[14] 王金环,张丽琴,雍彦礼,等.孙伟正教授应用“补脾益肾,酸甘化血”法治疗缺铁性贫血经验[J].中医药学报,2020,48(10):56-59.
[15] 黄娜娜,何希俊,李燕明,等.针刺背俞穴联合艾灸神阙穴与薯蓣丸治疗慢性疲劳综合征的对照研究[J].国医论坛,2021,36(5):29-31.
[16] 李妍妍,郑玉玲.郑玉玲教授运用薯蓣丸方治疗肺系疾病经验[J].中医研究,2020,33(12):31-35.
[17] 王玮,陈浩波.薯蓣丸加减治疗减肥致低体质指数型月经过少40例[J].浙江中医杂志,2021,56(3):160.
[18] Li HB,Liang WB,Zhou L. The experimental research on neuroplasticity in rats’ hippocampus subjected to chronic cerebral hypoperfusion and interfered by Modified Dioscorea Pills [J]. Heliyonm,2019,6(1):e02897.
[19] 谢文婷,谭子虎,陈延,等.加减薯蓣丸对轻、中度阿尔茨海默病的临床疗效及外周血IL-1β、 NF-κB 、miR-146a表达的影响[J].中国中西医结合杂志,2019,39(6):668-674.
[20] 米婷,喻嵘,苏丽清,等.薯蓣丸联合龙血竭胶囊对MKR转基因2型糖尿病小鼠创面愈合的影响[J].中国中西医结合杂志,2019,39(9):1110-1115.
[21] 王小燕,谭子虎,喻小明,等.基于Nlrp3/ASC/Caspase-1通路探讨加减薯蓣丸对APP/PS1痴呆小鼠神经炎症的影响[J].中国实验方剂学杂志,2021,27(3):8-14.
[22] 王奋勤,梁娟丽,王苗苗,等.生血宝合剂辅助治疗妊娠期缺铁性贫血效果及对孕妇MCV、SF及妊娠结局影响[J].中国计划生育学杂志,2020,28(7):1053-1055,1063.
[23] 尹璐瑶,梁旭东,武海荣,等.妊娠期缺铁性贫血的影响因素及琥珀酸亚铁片的治疗效果研究[J].现代生物医学进展,2021,21(9):1772-1776,1750.
[24] 程宇航,邱静,鄢文静,等.加减薯蓣丸对APP/PS1小鼠海马区AMPK/eEF2K/eEF2信号通路的影响[J].西部中医药,2021,34(3):30-34.
[25] 周艳,孙菲菲,张振凌,等.基于网络药理学探讨熟地黄临床用于治疗贫血的潜在作用机制[J].中华中医药学刊,2021,39(5):179-183,后插31-后插33.