Genotype distribution of CDKN2B gene rs1063192 locus in primary open-angle glaucoma of the Han nationality and its relationship with rs1063192 polymorphism
LU Yuqing1 WANG Ling2 XU Jing3 LI Lechao4 CAI Xin1▲
1.Department of Ophtalmology, Haian People’s Hospital, Jiangsu Province, Haian 226600, China;
2.Department of Ophtalmology, Wuxi People’s Hospital, Jiangsu Province, Wuxi 214023, China;
3.Department of Ophtalmology, Suzhou Ninth People’s Hospital, Jiangsu Province, Suzhou 215000, China;
4.Department of Neurology, Xuzhou Central Hospital, Jiangsu Province, Xuzhou 221000, China
Abstract:Objective To investigate the genotype distribution of CDKN2B gene rs1063192 locus in primary open-angle glaucoma (POAG) in the Han nationality and POAG relationship with the polymorphism of the genetic locus. Methods A total of 98 patients with POAG from Han nationality admitted to Haian People’s Hospital, Jiangsu Province (hereinafter referred to as “our hospital”) from May 2019 to 2021 were selected as the study group. The genotype distribution of CDKN2B gene rs1063192 locus in patients with different pathological characteristics was compared. Another 92 healthy subjects in our hospital at the same period were selected as the control group, the difference in genotype distribution of CDKN2B gene rs1063192 locus between the study group and the control group was compared. The relationship between rs1063192 genotype of CDKN2B gene and POAG in the Han nationality was analyzed. Results There were statistically significant differences in genotype distribution of CDKN2B gene rs1063192 locus in POAG patients with different ages, family history of glaucoma, and hypertension (P < 0.05). The genotypes of the two groups were consistent with Hardy-Weinberg genetic balance test (P > 0.05). The frequency of GG and AG genotypes at CDKN2B gene rs1063192 locus in study group were higher than that in control group, and the frequency of G allele was higher than that in control group (P < 0.05). The risk of POAG in the Han nationality with GG genotype was 3.177 times of that in the Han nationality with AA genotype, and the risk of POAG in the Han nationality with G allele was 2.751 times of that in the Han nationality with A allele (P < 0.05). Conclusion GG genotype and G allele of CDKN2B gene rs1063192 locus may be associated with the incidence of POAG in the Han nationality, and may increase the risk of POAG in the Han nationality.
陆宇清1 王玲2 徐静3 李乐超4 蔡鑫1▲. 汉族人群原发性开角型青光眼CDKN2B基因rs1063192位点基因型分布及其与rs1063192多态性的关系[J]. 中国医药导报, 2022, 19(24): 107-110.
LU Yuqing1 WANG Ling2 XU Jing3 LI Lechao4 CAI Xin1▲. Genotype distribution of CDKN2B gene rs1063192 locus in primary open-angle glaucoma of the Han nationality and its relationship with rs1063192 polymorphism. 中国医药导报, 2022, 19(24): 107-110.