Effect of Huoxue Tongmai Decoction soaking in the treatment of diabetic peripheral neuropathy
DENG Lijuan1 JU Shang2 YANG Bohua2 YANG Guangyao1 WANG Ning3 ZHANG Suming2 REN Yingying2 WANG Gang2▲#br#
1.The First Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Peripheral Vascular, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;
3.Department of Surgical, Beijing Shijingshan Hospital of Traditional Chinese Medicine, Beijing 100043, China
[Abstract] Objective To observe the effect of Huoxue Tongmai Decoction soaking in the treatment of diabetic peripheral neuropathy. Methods Sixty patients with diabetic peripheral neuropathy in Department of Peripheral Vascular, Dongzhimen Hospital from June 2019 to September 2020 were selected. They were divided into treatment group and control group according to the random number table method, with 30 cases in each group. In addition to the basic treatment of diabetes and oral administration of Mecobalamin, control group was treated with placebo soaking, and treatment group was treated with Huoxue Tongmai Decoction soaking. The treatment course lasted for 28 days. The curative effect of two groups was compared; sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) of common peroneal nerve and tibial nerve were observed before and after treatment; the contents of brain derived neurotrophic factor (BDNF) and myelin basic protein (MBP) of two groups were observed before and after treatment. Results The clinical efficacy of treatment group was better than control group (P < 0.05). After treatment, SNCV and MNCV of common peroneal nerve and tibial nerve in two groups were higher than those before treatment, and those in the treatment group were higher than those in the control group (P < 0.05). After treatment, the level of serum BDNF increased and the level of MBP decreased in both groups (P < 0.05); the level of serum BDNF in treatment group was higher than that in control group, while the level of MBP was lower than that in control group (P < 0.05). There were no obvious adverse reactions during the treatment. Conclusion Huoxue Tongmai Decoction soaking can enhance the nerve conduction velocity of patients with diabetic peripheral neuropathy, and improve the clinical symptoms of patients, and its mechanism may be related to the increase of BDNF contents and reduce of the MBP contents.
邓莉娟1 鞠上2 杨博华2 杨光耀1 王宁3 张素明2 任莹莹2 王刚2▲. 活血通脉方溻渍治疗对糖尿病周围神经病变的影响[J]. 中国医药导报, 2022, 19(24): 86-89.
DENG Lijuan1 JU Shang2 YANG Bohua2 YANG Guangyao1 WANG Ning3 ZHANG Suming2 REN Yingying2 WANG Gang2▲. Effect of Huoxue Tongmai Decoction soaking in the treatment of diabetic peripheral neuropathy. 中国医药导报, 2022, 19(24): 86-89.
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