Abstract：Objective To optimize the preparation process of breviscapine solid dispersion and determine its dissolution in vitro and content. Methods Taking the cumulative dissolution rate as the index, the best carrier and preparation method for preparing solid dispersion were selected through single factor test; the optimal ratio of drug and carrier material was investigated; the optimum preparation process of breviscapine solid dispersion was selected by orthogonal test; the reproducibility, dissolution, and content were investigated. Results The best preparation carrier of breviscapine solid dispersion was poloxamer 188; the best preparation method was melting method; the best preparation process of breviscapine solid dispersion was as follows: the ratio of drug to carrier material was 1∶5, the melting temperature was 70℃, and the cooling temperature was 20℃. Conclusion Breviscapine solid dispersion can improve its solubility.
唐婷 李福元 刘艳 邱艳明. 灯盏花素固体分散体制备工艺筛选[J]. 中国医药导报, 2022, 19(24): 22-25.
TANG Ting LI Fuyuan LIU Yan QIU Yanming . Screening of preparation process of breviscapine solid dispersion#br#. 中国医药导报, 2022, 19(24): 22-25.
京公网安备 11010502046598号