Application value of serum uric acid / creatinine ratio and N-terminal pro-brain natriuretic peptide level in prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease
WANG Libing1 ZHANG Xiaodong1 ZHANG Guirong1 DING Yihong2
1.Department of Pneumology, Tianchang Hospital of Traditional Chinese Medicine, Anhui Province, Tianchang 239300, China;
2.Department of Emergency, Fuyang People’s Hospital, Anhui Province, Fuyang 236000, China
Abstract：Objective To explore the application value of serum uric acid (UA) / creatinine (CR) ratio and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in predicting the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 82 patients with AECOPD admitted to Tianchang Hospital of Traditional Chinese Medicine, Anhui Province from October 2018 to October 2020 were selected as the study object, all patients were followed up for 12 months. According to the prognosis, they were divided into death group (10 cases) and survival group (72 cases). Serum UA / Cr and NT-proBNP levels of the two groups were compared to analyze the factors influencing the prognosis of AECOPD patients, and the value of serum UA / Cr and NT-proBNP levels in evaluating the prognosis of AECOPD. Results The mortality rate of AECOPD patients in this study was 12.20%. The levels of acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ) score, NT-proBNP, serum UA / Cr, and the proportion of Grade Ⅳ in death group were higher than those in survival group (P ＜ 0.05). Multivariate analysis showed that APACHE Ⅱ score, NT-proBNP, serum UA / Cr, and Grade Ⅳ were the influencing factors of death in AECOPD patients (P ＜ 0.05). Serum UA / Cr and NT-proBNP levels combined to predict the death of AECOPD patients had a higher area under the receiver operating characteristic curve than those predicted separately (P ＜ 0.05). Conclusion Serum UA / Cr and NT-proBNP are closely related to the severity and prognosis of AECOPD patients. Both alone and combined tests have high prognostic efficacy, and serum UA / Cr combined with NT-proBNP have higher prognostic efficacy.
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