Abstract：Objective To explore the evaluation value of clinical outcome in patients with acute ischemic stroke by glomerular filtration rate (GFR). Methods A total of 96 patients with acute ischemic stroke admitted to Yixing People’s Hospital, Jiangsu Province from January 2019 to January 2021 were selected. According to the modified Rankin scale score at six months after discharged, they were divided into poor group (mRS score ≥3 points, 39 cases) and good group (mRS score ＜ 3 points, 57 cases). The general data and laboratory indicators of the two groups at admission were compared, and the factors influencing the outcome of patients with acute ischemic stroke were analyzed by multivariate analysis, and the value of GFR in predicting the outcome of patients with acute ischemic stroke was analyzed by receiver operating characteristic (ROC) curve. Results The score of National Institutes of Health stroke scale (NIHSS) in the poor group was higher than that in the good group, and serum uric acid, glutamic-pyruvic transaminase, and GFR were lower than those in the good group (P ＜ 0.05). Multivariate analysis showed that scores of NIHSS, serum uric acid, and GFR were all influencing factors for the outcome of patients with acute ischemic stroke (P ＜ 0.05). ROC curve analysis showed that GFR had a cut-off value of 98.87 ml/(min·1.73m2), a sensitivity of 84.62%, a specificity of 92.98%, and an area under curve of 0.925 in predicting the outcome of acute ischemic stroke patients (P ＜ 0.05). Conclusion The GFR of patients with poor outcome of acute ischemic stroke is abnormally reduced, clinical monitoring of GFR can be used as a sensitive indicator to predict the poor outcome of patients with acute ischemic stroke.
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