Meta-analysis of the association between APOE e4 allele and mental behavioral symptoms in Alzheimer’s disease
MA Suya1 WEI Mingqing2 NI Jingnian2 LI Ting2 WANG Xu2 XU Xiaoqing2 LI Xiaohong3
1.Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Science, Beijing 100053, China;
2.Department of Encephalopathy, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100007, China;
3.Department of Internal Medicine of Traditional Chinese Medicine, the First School of Clinical Medicine College, Shandong University of Traditional Chinese Medicine the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250013, China
Abstract：Objective To systematically assess the association of APOE e4 allele with mental and behavioral symptoms of Alzheimer’s disease. Methods PubMed, Web of Science, Cochrane, Embase, and CNKI databases were searched, clinical study of screening mental behavioral symptoms and APOE e4 allele in Alzheimer’s disease. Self-built database until September 2020. Two researchers independently completed literature retrieval, quality evaluation, and data extraction, and Stata 15 software was used for data analysis. Results A total of 4 937 patients were included in 13 literatures. Agitation (Z = 0.31, P = 0.760), depression (Z = 1.71, P = 0.086), hallucinations (Z = 0.75, P = 0.456), delusions (Z = 1.80, P = 0.072), indifference (Z = 1.52, P = 0.128), nocturnal behavior abnormalities (Z = 1.70, P = 0.09) were not correlated with APOE e4 allele. Anxiety (Z = 4.38, P = 0.000) and abnormal behavior movement (Z = 2.16, P = 0.031) were correlated with APOE e4 allele. Conclusion The APOE e4 allele may be a risk gene for anxiety and abnormal behavior movement in psychobehavioral symptoms.
马素亚1 魏明清2 倪敬年2 李婷2 王旭2 徐筱青2 李晓红3. APOE e4等位基因与阿尔茨海默病精神行为症状关联的meta分析[J]. 中国医药导报, 2022, 19(23): 79-84.
MA Suya1 WEI Mingqing2 NI Jingnian2 LI Ting2 WANG Xu2 XU Xiaoqing2 LI Xiaohong3. Meta-analysis of the association between APOE e4 allele and mental behavioral symptoms in Alzheimer’s disease. 中国医药导报, 2022, 19(23): 79-84.
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