Predictive value of cardiac troponin I, high sensitivity-C-reactive protein, and N-terminal brain natriuretic peptide precursors for major adverse cardiovascular events in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention
TAO Hongzhi YU Guozhong
Department of Cardiovascular Medicine, Tongling Municipal Hospital, Anhui Province, Tongling 244000, China
Abstract：Objective To analyze the predictive value of cardiac troponin I (cTnI), high sensitivity C-reactive protein (hs-CRP), and N-terminal brain natriuretic peptide precursor (NT-proBNP) for major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). Methods From October 2017 to May 2021, 77 patients with STEMI who received PCI and treated successfully in Tongling Municipal Hospital were selected. According to whether MACE occurred within six months after surgery, they were divided into occurrence group (15 cases) and non-occurrence group (62 cases). Serum levels of cTnI, hs-CRP, and NT-proBNP were detected in all patients before PCI. Logistic multivariate regression was used to analyze risk factors, and the receiver operating characteristic (ROC) curve was used to analyze the predictive value. Results The age, proportion of pathological vessels≥2 cases, b-type natriuretic peptide, serum cTnI, hs-CRP, and NT-proBNP levels in the occurrence group were higher than those in the non-occurrence group (P ＜ 0.05). Logistic multivariate analysis showed that age (OR = 3.271, 95%CI:1.346-7.949, P ＜ 0.05) and proportion of pathological vessels≥2 cases (OR = 3.463, 95%CI:0.425-8.415, P ＜ 0.05), preoperative serum cTnI level (OR = 2.766, 95%CI:1.142-6.747, P ＜ 0.05), preoperative serum hs-CRP level (OR = 2.757, 95%CI:1.134-6.699, P < 0.05), and preoperative serum NT-proBNP level (OR = 3.846, 95%CI: 1.582-9.347, P < 0.05) were the influencing factors of MACE in STEMI patients within six months after PCI. ROC curve results showed that preoperative serum cTnI, hS-CRP, and NT-proBNP levels predicted the AUC values of MACE six months after PCI in STEMI patients were 0.811, 0.681 and 0.718, respectively. Conclusion The serum levels of cTnI, hs-CRP, and NT-proBNP have good value in predicting the occurrence of MACE in STEMI patients after PCI.
陶红志 余国忠. 心肌肌钙蛋白I、高敏-C反应蛋白、N末端脑钠肽前体对急性ST段抬高型心肌梗死患者经皮冠脉介入术后主要心血管不良事件的预测价值[J]. 中国医药导报, 2022, 19(23): 57-61.
TAO Hongzhi YU Guozhong. Predictive value of cardiac troponin I, high sensitivity-C-reactive protein, and N-terminal brain natriuretic peptide precursors for major adverse cardiovascular events in patients with acute ST-segment elevation myocardial infarction after percutaneous coronary intervention. 中国医药导报, 2022, 19(23): 57-61.
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