The correlation of thyroid function with coronary heart disease and lesion numbers
LI Jiadan1,2 PAN Liming1,2 WANG Jun1,2 XU Yong3
1.Department of Cardiology, Beijing Mentougou District Hospital, Beijing 102300, China;
2.Mentougou Teaching Hospital, Capital Medical University, Beijing 102300, China;
3.Department of Cardiology, the Six Medical Centre of Chinese People’s Liberation Army General Hospital, Beijing 100853, China
Abstract：Objective To investigate the correlation of thyroid function in normal range of thyroid stimulating hormone (TSH) with coronary heart disease and the number of lesion vessel. Methods A total of 258 inpatients in the Department of Cardiaology, Mentougou District Hospital of Beijing from January to Decmber in 2018 were retrospectively studied. According to the results of angiography, they were divided into coronary heart disease group(172 cases) and non-coronary heart disease group (86 cases). According to the number of stenosed coronary vessels, they were divided into 0 vessel group (86 cases), 1 vessel group (60 cases), 2 vessels group (56 cases) and 3 vessels group (56 cases). Fasting blood was collected to detect thyroid function related indicators total triiodothyronine (TT3), free T3 (FT3), free thyroxine (FT4) and TSH. and the differences and correlation analysis of each index between groups were compared. Results The level of TSH in coronary heart disease group was higher than that in non-coronary heart disease group, the difference was statistically significant (P ＜ 0.05). Univariate regression analysis showed that TSH (OR = 1.385, 95%CI:1.068-1.797, P ＜ 0.05), and multivariate regression analysis showed that TSH (OR = 1.362, 95%CI: 1.049-1.768, P ＜ 0.05) was an independent risk factor for coronary heart disease. There were statistically significant differences in TSH among groups with 0, 1, 2 and 3 vessel lesions groups (P ＜ 0.05). In univariate linear regression analysis, TSH (β=0.303, 95%CI: 0.172-0.433, P ＜ 0.001) and the number of coronary artery lesions. Multiple linear regression analysis showed that the regression equation was: the number of coronary artery lesions =0.669+0.316×TSH. Conclusion TSH level in the normal range is an independent risk factor for CHD, and has a linear correlation with the number of coronary artery lesions
李佳丹1,2 潘黎明1,2 王军1,2 徐勇3. 甲状腺功能与冠心病及病变支数的相关性研究[J]. 中国医药导报, 2022, 19(23): 44-48.
LI Jiadan1,2 PAN Liming1,2 WANG Jun1,2 XU Yong3. The correlation of thyroid function with coronary heart disease and lesion numbers. 中国医药导报, 2022, 19(23): 44-48.
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