Abstract：Objective To explore the medication rule of Professor Lü Wenliang in the treatment of chronic hepatitis B based on data mining, and to hope to provide reference for clinical treatment. Methods From January 2020 to July 2021, patients clearly diagnosed with chronic hepatitis B visited the expert outpatient clinic of Professor Lü at Department of Infectious Diseases, Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences were selected, and the clinical cases were real, complete and effective. The clinical case data were screened and a database was constructed, and data mining methods such as frequency statistics, association rule analysis, cluster analysis, complex system entropy clustering, and entropy tomographic clustering analysis were used to explore their medication rules. Results A total of 116 prescriptions were included, involving 153 traditional Chinese medicines. There were 13 traditional Chinese medicines with the use frequency of more than 50%, among which, the use frequency of raw Astragali Radix exceeded 95%. There were a total of ten drug combinations with frequency of usage ≥76, of which raw Astragali Radix, Scutellariae Radix, fried Atractylodis Macrocephalae Rhizoma, Saposhnikoviae Radix, Coptidis Rhizoma, Poria, scorched Crataegi Fructus, fried Armeniacae Semen Amarum, Phellodendri Chinensis Cortex were nine high frequency drugs. The drug properties were mainly cold and warm, and the drug tastes were mainly bitter and sweet, which were mainly attributed to the spleen, stomach, lung and liver channels. In the end, 14 pairs of core drug combinations and 14 new derivatives were selected and extracted. Conclusion Professor Lü takes the main treatment methods of enhancing qi and invigorating spleen, simultaneously dispersing stagnated liver qi, clearing dampness and heat, and directly eliminating poisonous pathogens, and can increase or decrease the drug according to the dynamic changes of the patient’s symptoms and disease stage. This study can provide a reference for Chinese medicine treatment of chronic hepatitis B.
强睿 冯佳琪 吕文良. 基于数据挖掘探析吕文良教授治疗慢性乙型肝炎的用药规律[J]. 中国医药导报, 2022, 19(22): 104-109,113.
QIANG Rui FENG Jiaqi LYU Wenliang. Medication rule analysis of Professor Lü Wenliang in the treatment of chronic hepatitis B based on data mining. 中国医药导报, 2022, 19(22): 104-109,113.
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