Effects of epidural and thoracic paravertebral nerve block on analgesia, oxidative stress, and immune function in patients undergoing radical resection of lung cancer
LI Xiang SUN Qichao DING Hairu#br#
Department of Cardiothoracic Surgery, Rugao Hospital Affiliated to Nantong University Rugao People’s Hospital, Jiangsu Province, Rugao 226500, China
Abstract：Objective To investigate the effects of epidural and thoracic paravertebral nerve block on analgesia, oxidative stress, and immune function in patients undergoing radical resection of lung cancer. Methods A total of 86 patients undergoing radical resection of lung cancer in Rugao Hospital Affiliated to Nantong University from June 2017 to May 2020 were selected, they were divided into epidural group (underwent epidural nerve block, 43 cases) and thoracic paravertebral group (underwent thoracic paravertebral nerve block, 43 cases) by random number table method. Operation time and anesthesia maintenance time were compared between two groups; visual analogue scale (VAS) scores were compared between two groups at 4, 12, 24, and 48 h postoperatively; stress response and immune function indexes were compared between two groups before operation and at 4, 12, and 48 h postoperatively. Results There were no statistically significant differences in operation time and anesthesia maintenance time between two groups (P > 0.05). Comparison of VAS scores at different time points between the two groups showed statistical significance (P < 0.05). VAS scores in thoracic paravertebral group at 4, 12, 24, and 48 h postoperatively were lower than those in epidural group (P < 0.05). The levels of Cor and Ang Ⅱ in two groups at 4, 12, and 48 h postoperatively were higher than those before operation (P < 0.05). The levels of Cor and Ang Ⅱ in thoracic paravertebral group were lower than those in epidural group at 4, 12, and 48 h postoperatively (P < 0.05). CD3+, CD4+, CD8+, and CD4+/CD8+ at 4, 12, and 48 h postoperatively were lower than those before operation (P < 0.05). CD3+, CD4+, and CD4+/CD8+ in thoracic paravertebral group at 4, 12, and 48 h postoperatively were higher than those in epidural group (P < 0.05). Conclusion Compared with epidural nerve block, thoracic paravertebral nerve block can alleviate the postoperative radical resection of lung cancer patients pain, reduce oxidative stress, and reduce immune suppression.
李响 孙启超 丁海如. 硬膜外与胸椎旁神经阻滞对肺癌根治术患者镇痛、氧化应激及免疫功能的影响[J]. 中国医药导报, 2022, 19(22): 96-99.
LI Xiang SUN Qichao DING Hairu. Effects of epidural and thoracic paravertebral nerve block on analgesia, oxidative stress, and immune function in patients undergoing radical resection of lung cancer. 中国医药导报, 2022, 19(22): 96-99.
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