Abstract：Objective To investigate the relationship between human GB virus type C (GBV-C) virus infection and non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). Methods PubMed, Web of Science, Embase, CNKI, Wanfang database were searched for literatures on the relationship between GBV-C virus infection and NHL and HL. The search time was from January 1990 to July 2021. Two researchers independently screened the literature, extracted data and evaluated the literature. Data was analyzed by using Stata 14.0 software. Results Ten studies were included. Meta analysis showed that GBV-C infection increased the risk of NHL (RR = 2.36, 95%CI: 1.52-3.66, P = 0.0001). Subgroup analysis showed that GBV-C in North America (RR = 2.36, 95%CI: 1.51-3.68, P ＜ 0.001) and GBV-C in Europe (RR = 2.57, 95%CI: 1.41-4.68, P = 0.009) were associated with NHL. Matched GBV-C was associated with NHL (RR = 2.18, 95%CI: 1.23-3.83, P ＜ 0.001). GBV-C of NHL in B cells was related to NHL (RR = 2.12, 95%CI: 1.28-3.51, P ＜ 0.001). Meta analysis showed that GBV-C infection was related to follicular B-cell NHL (RR = 2.06, 95%CI: 1.58-2.67, P ＜ 0.001) and diffuse B-cell NHL (RR = 1.54, 95%CI: 1.16-2.03, P = 0.047). GBV-C infection was not associated with HL (RR = 1.43,95%CI:0.88-2.33, P = 0.15). Conclusion GBV-C infection is closely related to NHL and has nothing to do with HL, so it is suggested to focus on it in clinical work.
谢文蕊1 符正奇1 邓程伟1 张志东2▲. GBV-C病毒感染与非霍奇金淋巴瘤及霍奇金淋巴瘤关系的meta分析[J]. 中国医药导报, 2022, 19(20): 87-91.
XIE Wenrui1 FU Zhengqi1 DENG Chengwei1 ZHANG Zhidong2▲. Meta analysis of the association between GBV-C virus infection and non-Hodgkin lymphoma and Hodgkin lymphoma. 中国医药导报, 2022, 19(20): 87-91.
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