Clinical significance of the expression of miR-590 and miR-16 in hysteromyoma tissue
HUANG Yan1 ZHOU Yuzhen1 PAN Xiaohong2 ZHU Qianmeng1 ZHANG Yuying1▲#br#
1.Department of Obstetrics and Gynecology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Jiangsu Province, Suzhou 215101, China;
2.Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Soochow University, Jiangsu Province, Suzhou 215100, China
Abstract：Objective To explore clinical significance of the expression of microribonucleic acid-590 (miR-590) and miR-16 in hysteromyoma tissue. Methods One hundred and eighty-six patients with hysteromyoma treated in Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Jiangsu Province from October 2018 to August 2020 were selected as study group, a total of 120 patients with uterine prolapse were selected as the control group. The expression levels of miR-590 and miR-16 in hysteromyoma tissue and normal uterine tissues were detected by real-time quantitative PCR. The influencing factors of hysteromyoma was explored by using multivariate logistic regression analysis. Pearson correlation was used to analyze the relationship between the expression levels of miR-590, miR-16 and the size, number of hysteromyoma. Results The expression level of miR-590 in study group was higher than that in control group, and the expression level of miR-16 was lower than that in control group (P < 0.05). The proportion of diabetes mellitus, menstrual disorders, and reproductive tract inflammation in study group were higher than those in control group, the number of miscarriages in study group was more than that in control group (P < 0.05). Logistic regression analysis showed that menstrual disorder, genital tract inflammation, and the expression levels of miR-590 and miR-16 in uterine tissue were the influencing factors of hysteromyoma (OR = 2.818, 2.751, 3.888, 3.476, P ＜ 0.05). The expression level of miR-590 was positively correlated with the size and number of hysteromyomas (r = 0.767, 0.795, P < 0.05). The expression level of miR-16 was negatively correlated with the size and number of hysteromyomas (r = -0.743, -0.792, P < 0.05). Conclusion MiR-590 is highly expressed in hysteromyoma tissue while miR-16 is low. The expression levels of miR-590 and miR-16 are related to the occurrence of hysteromyoma.
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