Effects of Dexmedetomidine combined with intraoperative warming on hypoxic brain injury and cellular immunity in patients undergoing radical resection of colorectal cancer
SONG Xiaotao1 LI Minghui2 FENG Haihong2 GUO Fei2 YAO Jie3 WU Xueliang2
1.Operating Room, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
2.Department of General Surgery, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China;
3.Department of Anesthesiology, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China
[Abstract] Objective To explore the effect of comprehensive intraoperative warming nursing on hypoxic brain injury and cellular immunity in patients undergoing radical resection of colorectal cancer. Methods A total of 100 patients who undergoing radical resection of rectal cancer in the First Affiliated Hospital of Hebei North University from March 2019 to March 2020 were selected as the research subjects. The patients were divided into two groups by random number table method, with 50 cases in each group. The control group was given Dexmedetomidine, and the observation group was given Dexmedetomidine combined with comprehensive intraoperative warming nursing intervention. The scores of mini-mental state scale (MMSE), cellular immune function, interleukin-6 (IL-6), C-reactive protein (CRP), the change of tumor necrosis factor-α (TNF-α), the post-operative cognitive dysfunction (POCD), and complications of the two groups were counted. Results Before surgery, there was no significant difference in MMSE score between the two groups (P ＞ 0.05). The MMSE scores of the control group one and three days after operation were lower than those before operation, and the differences were statistically significant (P ＜ 0.05). MMSE scores of observation group were higher than control group one and three days after operation, the differences were statistically significant (P ＜ 0.05). Before surgery, there were no significant differences in CD4+, CD8+, CD4+/CD8+ between the two groups (P ＞ 0.05). One and threee days after operation, CD4+, CD8+, and CD4+/CD8+ were lower than those before operation, the differences were statistically significant (P ＜ 0.05). One and three days after operation, CD4+, CD8+, and CD4+/CD8+ in the observation group were higher than those in the control group, the differences were statistically significant (P ＜ 0.05). Before operation, there were no significant differences in IL-6, TNF-α, and CRP between the two groups (P ＞ 0.05). One and three days after operation, IL-6, TNF-α, and CRP in two groups were significantly higher than those before operation (P ＜ 0.05). One and threee days after operation, IL-6, TNF-α, and CRP in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). One and threee days after operation, the incidence of POCD in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Comprehensive intraoperative warming nursing intervention for patients undergoing radical resection of colorectal cancer has an ideal effect. It can promote the recovery of patients’ cognitive function, reduce the patient’s cellular immune suppression state and the secretion of inflammatory factors, thereby reducing the incidence of POCD and complications.
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（收稿日期：2022-0
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