Research progress on molecular biomarkers of endometrial atypical hyperplasia
LYU Mingyi1 SUN Huiting2 LIU Huijun2 WANG Linxiao3 LIU Sufen4#br#
1.Graduate School, Dalian Medical University, Liaoning Province, Dalian 116044, China;
2.Reproductive Center, the Affiliated Changzhou Second People’s Hospital, Nanjing Medical University, Jiangsu Province, Changzhou 213000, China; 3.Central Laboratory, the Affiliated Changzhou Second People’s Hospital, Nanjing Medical University, Jiangsu Province, Changzhou 213000, China; 4.Department of Gynecology, the Affiliated Changzhou Second People’s Hospital, Nanjing Medical University, Jiangsu Province, Changzhou 213000, China
Abstract：Endometrium atypical hyperplasia (EAH) is the precancerous lesion of endometrial cancer, its incidence rate is increasing year by year. With the continuous updating of the screening methods, the detection methods of EAH lesions are constantly updated. At present, the most commonly used detection method in clinic is histopathological examination, but there is no specific molecular biomarker. This paper reviews the recent advances in molecular biomarkers for diagnosis of EAH, such as steroid hormone receptors (estrogen receptors, progesterone receptors), proto-oncogenes and tumor suppressor genes (B-lymphocytoma-2, phosphatase and tensin homologues, P53, and AT-rich domain protein 1A), microRNA and their research status was analyzed.
吕明医1 孙慧婷2 刘慧君2 王林晓3 刘素芬4. 子宫内膜不典型增生的分子生物学标志物的研究进展[J]. 中国医药导报, 2022, 19(19): 57-60.
LYU Mingyi1 SUN Huiting2 LIU Huijun2 WANG Linxiao3 LIU Sufen4. Research progress on molecular biomarkers of endometrial atypical hyperplasia. 中国医药导报, 2022, 19(19): 57-60.
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