Clinical effect of acupotomy treating knee osteoarthritis base on the theory of infrapatcllar fat
YE Xixi1 FAN Pei1 LU Di1 ZHOU Yi1 LI Kaiping2
1.The Second Affiliate Hospital of Wenzhou Medical University, Zhejiang Province, Wenzhou 325000, China;
2.Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210000, China
Abstract:Objective To dicuss the clinical effect of acupotomy treating knee osteoarthritis base on the theory of infrapatcllar fat. Methods A total of 70 knee osteoarthritis patients who were treated in the Second Affiliate Hospital of Wenzhou Medical University from April 2020 to April 2021, and they were divided into experimental group and control group by random number table method, with 35 cases in each group. The experimental group treated with fan-shaped release infrapatcllar fat and traditional operate release,the control group treated with traditional operate release, treatment once a week, a total of four treatments. The visual analog scale (VAS) and Lysholm score were evaluated before treatment, one week after treatment, and three months after treatment, and the curative effect was evaluated. Results One weeks and three months after treatment,VAS scores in two groups were lower than those before treatment, and those in the experimental group were lower than the control group, Lysholm scores in two groups were higher than those before treatment, and those in the experimental group were higher than the control group, the differences were statistically significant (P < 0.05). The curative effect of the experimental group was better than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Fan-shaped release infrapatcllar fat pad and traditional operate release can relieve knee pain and mobility disorders more effectively, which is worthy of clinical promotion.
叶喜喜1 樊沛1 卢迪1 周奕1 李开平2. 基于髌下脂肪垫理论针刀治疗膝骨关节炎的临床效果[J]. 中国医药导报, 2022, 19(18): 128-131.
YE Xixi1 FAN Pei1 LU Di1 ZHOU Yi1 LI Kaiping2. Clinical effect of acupotomy treating knee osteoarthritis base on the theory of infrapatcllar fat. 中国医药导报, 2022, 19(18): 128-131.
[1] 高宏伟.鹿茸提取物调控软骨细胞的生物学机制研究[D].长春:长春中医药大学,2020.
[2] 霍少川,王海彬,唐宏宇,等.补肾健脾活血中药干预膝骨关节炎模型大鼠软骨细胞IL-1β/ERRα/SOX9/Col2α1信号通路的变化[J].中国组织工程研究,2020,24(35):5577-5581.
[3] Clockaerts S,Bastiaansen-Jenniskens YM,Runhaar J,et al. The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review [J]. Osteoarthritis Cartilage,2010,18(7):876-82.
[4] 蔡静玉.膝骨关节炎患者髌骨下脂肪垫与膝关节疼痛及关节结构改变的相关性研究[D].合肥:安徽医科大学,2016.
[5] 中华医学会风湿病学分会.骨关节炎诊断及治疗指南[J].中华风湿病学杂志,2010,14(6):416-419.
[6] 中华中医药学会.骨伤临床疾病指南[M].南京:人民卫生出版社,2015:53.
[7] 芦丹,汪亚群,俞杭平,等.膝骨性关节炎临床分期与膝关节角的关系研究[J].中华全科医学,2017,15(10):1818-1820.
[8] 邓星佑,熊尤龙,武双艳,等.辨证取穴针刺法对膝关节骨性关节炎患者血清MMP、IL-1β表达的影响[J].辽宁中医杂志,2019,46(5):1048-1051.
[9] 熊应宗,朱俊琛,王超,等.针刀联合塞来昔布治疗膝骨关节炎的临床疗效观察[J].中国中医骨伤科杂志,2020, 28(2):19-23.
[10] Lysholm J,Gillquist J. Evaluation of knee ligament surgery results with special emphasis on use of a scoring scale [J]. Am J Sports Med,1982,10(3):150-154.
[11] 国家中医药管理局发布.中医病证诊断疗效标准:ZY/T 001.1~001.9-94[J].南京:南京大学出版社,1994.
[12] 王明杰,王悦良,周学龙,等.瑶医油针运动针刺治疗湿热痹阻型膝关节炎的临床研究[J].中华中医药杂志,2021, 36(8):5087-5091.
[13] 中华医学会骨科学分会关节外科学组,中国医师协会骨科医师分会骨关节炎学组,国家老年疾病临床医学研究中心(湘雅医院),等.中国骨关节炎诊疗指南(2021年版)[J].中华骨杂志,2021,41(18):1291-1314.
[14] 胡国强,薛宝山,刘际石,等.基于人体弓弦力学理论探讨针刀治疗膝骨关节炎的临床效果[J].中国医药导报,2021,18(18):172-175.
[15] 吴松,巴宏亮,何金深,等.髌下脂肪垫MRI信号与膝关节骨关节炎相关性的横断面研究[J].中南大学学报(医学版),2017,42(5):536-541.
[16] 陈益丹,邱华平,金肖青,等.不同针灸方法对膝骨关节炎模型细胞因子及基质金属蛋白酶影响的比较研究[J].中国比较医学杂志,2016,26(1):42-45.
[17] Paré F,Tardif G,Fahmi H,et al. In vivo protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice [J]. Aging (Albany NY),2020,12(3):2880-2896.
[18] Lee JH,Ort T,Ma K,et al. Resistin is elevated following traumatic joint injury and causes matrix degradation and release of inflammatory cytokines from articular cartilage in vitro [J]. Osteoarthritis Cartilage,2009,17(5):613-620.
[19] Wang B,Lang Y,Zhang L. Histopathological changes in the infrapatellar fat pad in an experimental rabbit model of early patellofemoral osteoarthritis [J]. Knee,2019,26(1):2-13.
[20] Belluzzi E,Macchi V,Fontanella CG,et al. Infrapatellar Fat Pad Gene Expression and Protein Production in Patients with and without Osteoarthritis [J]. Int J Mol Sci,2020,21(17):6016.
[21] 俞杰,明顺培.针刀疗法对兔膝骨关节炎关节液中IL-1β、IL-6、TNF-α水平的影响[J].中国中医骨伤科杂志,2002,10(4):15-18.
[22] 黄超,吕松岑.髌下脂肪垫紊乱的研究进展[J].临床外科杂志,2015,23(5):392-394.
[23] 王智明,陈文玉,王娟娟,等.三点法针刀松解髌下脂肪垫治疗膝关节疼痛的临床研究[J].中国中医骨伤科杂志,2015,23(9):22-25.
[24] 李津,彭秀娟,张平,等.近5年膝骨性关节炎的针灸选穴分析[J].湖北中医志,2020,42(10):60-62.
[25] 朱芮,袁普卫,董博,等.近五年来膝骨关节炎的针灸治疗概况[J].中国医药导报,2021,18(13):35-38.
[26] 刘浪,安璐,莫易方,等.不同针灸疗法防治膝骨性关节炎的临床研究进展[J].中国当代医药,2020,27(33):21-24.
[27] 林宇进,高兴华,黄保华,等.髌下脂肪垫血供特点及在TKA术中的意义[J].中国临床解剖学杂志,2011,29(1):31-33.
[28] 陈俊,官燕玲,陈帅,等.严重膝关节骨性关节炎患者是否保留髌下脂肪垫的X线扫描变化预测膝前痛情况的随访研究[J].临床和实验医学杂志,2020,19(15):1648-1652.