Research progress on the mechanism of traditional Chinese medicine treatment of depression complicated with coronary heart disease based on cell pyroptosis
LI Lanshi1 WANG Ying2
1.Graduate School, Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110032, China;
2.Clinical Teaching and Research Department of Acupuncture, Liaoning University of Traditional Chinese Medicine, Liaoning Province, Shenyang 110032, China
Abstract：Depression and coronary heart disease are both chronic inflammatory diseases, the harms of inflammatory responses in the occurrence and development of the two diseases have been recognized. It was found that the rates of incidence and mortality of coronary heart in depression patients were increasing day by day. Recently studies had found that depression caused a variety of individual brain cells pyroptosis especially the microglia pyroptosis, it could promote the highly pro-inflammatory programmed cell death mode. And the cascaded inflammation responces caused by pyroptosis in the brain are an important molecular mechanism that may induces vascular endothelial injurying, atherosclerosis, and ultimately coronary heart disease for depressed patients. At the same time, a large number of cells, animals, and clinical experiments had proved that a variety of traditional Chinese medicine could treat depression combined with coronary heart disease by regulating the expression of various proteins about pyroptosis, and the curative effect was significant. This paper intends to sort out the specific mechanism of traditional Chinese medicine action from the perspective of cell pyroptosis, hoping to provide new ideas and possibilities for clinical prevention and treatment of depression complicated with coronary heart disease.
李兰石1 王颖2. 基于细胞焦亡的中药治疗抑郁症合并冠心病的机制研究进展[J]. 中国医药导报, 2022, 19(18): 38-41.
LI Lanshi1 WANG Ying2. Research progress on the mechanism of traditional Chinese medicine treatment of depression complicated with coronary heart disease based on cell pyroptosis. 中国医药导报, 2022, 19(18): 38-41.
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