胃癌组织中lncRNA UCA1、miR-590-3p表达及与病理参数和预后的关系

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摘要目的探讨胃癌组织中长链非编码RNA（lncRNA）尿路上皮癌相关基因1（UCA1）、微小RNA（miR）-590-3p表达及与病理参数和预后的关系。方法选取2017年1月至2018年7月河北省唐山市中医医院收治的107例胃癌患者，qRT-PCR检测癌组织和癌旁组织中lncRNA UCA1和miR-590-3p的表达。分析胃癌组织中lncRNA UCA1与miR-590-3p表达的相关性及与病理参数的关系。K-M法绘制不同lncRNA UCA1和miR-590-3p表达的胃癌患者生存曲线。结果胃癌组织中lncRNA UCA1表达高于癌旁组织，miR-590-3p表达低于癌旁组织（P ＜ 0.05）。Pearson相关性分析显示，胃癌组织中lncRNA UCA1与miR-590-3p表达呈负相关（r = -0.720，P ＜ 0.01）。不同临床病理分期和淋巴结转移患者lncRNA UCA1和miR-590-3p表达比较，差异有统计学意义（P ＜ 0.05）。K-M生存曲线显示，高lncRNA UCA1表达组累积生存率低于低lncRNA UCA1表达组，高miR-590-3p表达组累积生存率高于低miR-590-3p表达组（χ2=8.140、11.624；P = 0.004、0.001）。结论胃癌组织中lncRNA UCA1高表达，miR-590-3p低表达，与临床病理分期、淋巴结转移和预后有关，可能作为预后评估指标。

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	李艳梅1 李伟2 王海芹1

关键词 ：胃癌, 长链非编码RNA, 尿路上皮癌相关基因1, 微小RNA-590-3p, 预后

Abstract：Objective To investigate the expression of long non-coding RNA (lncRNA) urothelial cancer associated 1 (UCA1) and microRNA (miR)-590-3p in gastric cancer tissues and the relationship with pathological parameters and prognosis. Methods A total of 107 case of gastric cancer patients admitted to Tangshan Hospital of Traditional Chinese Medicine of Hebei Province from January 2017 to July 2018 were selected, and lncRNA UCA1, miR-590-3p expression were detected in cancer and cancer-adjacent tissues by qRT-PCR. The correlation between lncRNA UCA1 and miR-590-3p expression in gastric cancer tissues and the relationship with pathological parameters were analysed. Survival curves of patients with different lncRNA UCA1, miR-590-3p expression in gastric cancer were plotted using the K-M method. Results The expression of lncRNA UCA1 in gastric cancer tissues was higher than that in cancer-adjacent tissues, and the expression of miR-590-3p was lower than that in cancer-adjacent tissues (P ＜ 0.05). Pearson correlation analysis showed that lncRNA UCA1 was negatively correlated with miR-590-3p expression in gastric cancer tissues (r = -0.720, P ＜ 0.01). The expression of lncRNA UCA1 and miR-590-3p in patients with different clinicopathological stages and with or without lymph node metastasis was significantly different (P ＜ 0.05). K-M survival curve showed that the cumulative survival rate of high lncRNA UCA1 expression group was lower than that of low lncRNA UCA1 expression group, and the cumulative survival rate of high miR-590-3p expression group was higher than that of low miR-590-3p expression group (χ2=8.140, 11.624; P = 0.004, 0.001). Conclusion High expression of lncRNA UCA1 and low expression of miR-590-3p in gastric cancer tissues are associated with clinicopathological stages, lymph node metastasis, and prognosis, and may be used as indicators for prognostic assessment.

Key words： Gastric cancer Long non-coding RNA Urothelial cancer associated 1 MicroRNA-590-3p Prognosis

基金资助:河北省中医药管理局科研计划项目（2018315）。

引用本文:

李艳梅1 李伟2 王海芹1. 胃癌组织中lncRNA UCA1、miR-590-3p表达及与病理参数和预后的关系[J]. 中国医药导报, 2022, 19(17): 127-130.
LI Yanmei1 LI Wei2 WANG Haiqin1. Expression of lncRNA UCA1, miR-590-3p in gastric cancer tissues and the relationship with pathological parameters and prognosis. 中国医药导报, 2022, 19(17): 127-130.

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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I17/127

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