Relationship between urinary FSP-1, β2-MG and severity of henoch-schonlein purpura in children and prognosis factors analysis
WANG Liang LI Yanling ZHANG Wenhua
Department of Pediatrics, the First Affiliated Hospital of Anhui University of Science and Technology Huainan First People’s Hospital, Anhui Province, Huainan 232007, China
Abstract：Objective To investigate the severity of urinary fibroblast marker protein-1 (FSP-1), β2-microglobulin (β2-MG) of children with henoch-schonlein purpura (HSP) and the factors affecting prognosis. Methods From January 2018 to December 2020, 110 children with HSP admitted to the Department of Pediatrics, the First Affiliated Hospital of Anhui University of Science and Technology (“our hospital” for short) were selected as HSP group. During the same period, 100 healthy children who came to our hospital for health consultation were control group. The levels of urinary FSP-1 and β2-MG were compared between two groups, and the correlation between the levels and purpura symptoms scores was analyzed. The children were divided into kidney injury group and non-injury group according to whether kidney injury occurred within one week after admission, and the risk factors influencing poor prognosis of HSP were analyzed. Results The levels of urinary FSP-1 and β2-MG in HSP group were higher than those in control group, and the differences were statistically significant (P ＜ 0.05). Pearson correlation analysis showed that urinary FSP-1 and β2-MG levels were positively correlated with purpura symptom scores (r ＞ 0, P ＜ 0.05). There were 35 cases of renal injury in 110 cases, and there were statistically significant differences in abdominal pain, IgA, urinary FSP-1, urinary β2-MG, and purpura symptom scores between two groups (P < 0.05). Logistic regression analysis showed that abdominal pain, IgA, urinary FSP-1, β2-MG, and purpura symptom score were the effect factors for poor prognosis (OR > 1, P < 0.05). Conclusion Abnormal levels of urinary FSP-1 and β2-MG in children with HSP and positively correlated with the severity of the disease, which are risk factors leading to poor prognosis.
王亮 李艳玲 张文化. 尿FSP-1、β2-MG与过敏性紫癜患儿病情严重程度的关系及预后影响因素分析[J]. 中国医药导报, 2022, 19(17): 104-107.
WANG Liang LI Yanling ZHANG Wenhua. Relationship between urinary FSP-1, β2-MG and severity of henoch-schonlein purpura in children and prognosis factors analysis. 中国医药导报, 2022, 19(17): 104-107.
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