Relationship between serum vitamin A, D, and E levels with early-onset sepsis in preterm infants based on propensity score matching
ZHANG Yinying1 JI Xiaoyi2 LI Ye1
1.Department of Clinical Pharmacy, Jiaxing Maternity and Child Health Care Hospital, Zhejiang Province, Jiaxing 314000, China;
2.Department of Pediatrics, Jiaxing Maternity and Child Health Care Hospital, Zhejiang Province, Jiaxing 314000, China
Abstract：Objective To investigate the relationship between serum vitamin A (Vit A), Vit D and Vit E levels with early-onset sepsis (EOS) in preterm infants. Methods Fifty-four preterm infants diagnosed with EOS in Jiaxing Maternal and Child Health Hospital of Zhejiang Province from January 2019 to December 2020 were selected as the EOS group, 127 premature infants without sepsis during the same period were the control group. The 1∶1 propensity score matching (PSM) was used to balance the confounding factors between groups, Vit A, Vit D, and Vit E levels and deficiency rates were compared between groups, logistic regression analysis was used to evaluate the relationship between EOS and vitamin levels in premature infants. Results A total of 33 pairs of premature infants were successfully matched after PSM. There was no significant difference in serum Vit A and Vit E levels between the two groups (P > 0.05); the serum 25 (OH) Vit D level in EOS group was lower than that in control group, and the difference was statistically significant (P < 0.05). There was no significant difference in serum Vit A and Vit E deficiency rates between the two groups (P > 0.05); the serum 25 (OH) Vit D deficiency rate in EOS group was higher than that in control group, and the difference was statistically significant (P < 0.05). Logistic regression analysis showed that high level of 25 (OH) Vit D was an protective factor for the occurrence of EOS in premature infants (OR = 0.867, 95%CI:0.793-0.947, P ＜ 0.05). Conclusion Serum Vit D level was an important factor in the occurrence of EOS in premature infants, but Vit A and Vit E were not found to be associated with EOS in premature infants.
张寅英1 纪小艺2 李晔1. 基于倾向性评分匹配的血清维生素A、D、E水平与早产儿早发型败血症的关系[J]. 中国医药导报, 2022, 19(15): 109-112.
ZHANG Yinying1 JI Xiaoyi2 LI Ye1. Relationship between serum vitamin A, D, and E levels with early-onset sepsis in preterm infants based on propensity score matching. 中国医药导报, 2022, 19(15): 109-112.
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