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平滑肌电刺激与曲安奈德治疗外阴硬化性苔藓的临床效果
刘念1      赵骏达1      刘娅2      马俊旗1
1.新疆医科大学第一附属医院妇科,新疆乌鲁木齐   830000;
2.山东省菏泽市立医院妇科,山东菏泽   274000
Clinical effect of vascular smooth muscle electrical stimulation and triamcinolone acetonide of the patients with vulvar lichen sclerosus
LIU Nian1   ZHAO Junda1   LIU Ya2   MA Junqi1
1.Department of Gynecology, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi   830000, China; 2.Department of Gynecology, Heze Municipal Hospital, Shandong Province, Heze   274000, China
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摘要 目的 比较血管平滑肌电刺激与曲安奈德治疗外阴硬化性苔藓的效果。 方法 选择2015年1月至2020年1月就诊于新疆医科大学第一附属医院的外阴硬化性苔藓患者58例,根据患者的随访条件及意愿分为物理治疗组(21例)、药物治疗组(37例)。物理治疗组主要针对下肢及盆底的血管、淋巴系统进行电刺激治疗;药物治疗组采用曲安奈德益康唑乳膏治疗。比较两组治疗前及治疗后1、3、6、12个月的症状和体征评分及生活质量指数评分,观察不良反应发生情况。 结果 物理治疗组治疗后12个月症状评分低于药物治疗组(P < 0.05)。物理治疗组治疗后1个月体征评分高于药物治疗组(P < 0.05)。物理治疗组治疗后1、6个月生活质量评分低于药物治疗组(P < 0.05)。物理治疗组治疗后3、6、12个月性生活评分低于药物治疗组(P < 0.05)。物理治疗组治疗后1、6、12个月睡眠焦虑评分低于药物治疗组(P < 0.05)。物理治疗组中1例合并糖尿病的患者出现外阴阴道假丝酵母菌病,治愈后继续治疗;药物治疗组有2例局部瘙痒感加重,出现刺痛、红肿,停药。长期用药随访中,5例患者出现瘙痒不能缓解,局部出现血管扩张,色素沉着的药物不良反应,停药。 结论 血管平滑肌电刺激治疗外阴硬化性苔藓副作用少、安全、有效,在改善症状、性生活质量、睡眠焦虑方面的长期疗效有优势。
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刘念1 赵骏达1 刘娅2 马俊旗1
关键词 血管平滑肌电刺激曲安奈德外阴硬化性苔藓生活质量    
Abstract:Objective To compare the effect of vascular smooth muscle electrical stimulation and triamcinolone acetonide in the treatment of vulvar lichen sclerosus. Methods A total of 58 patients with vulvar lichen sclerosus in the First Affiliated Hospital of Xinjiang Medical University from January 2015 to January 2020 were selected, they were divided into physical therapy group (21 cases) and drug therapy group (37 cases) according to follow-up conditions and wills. In physical therapy group, the vascular and lymphatic systems of the lower limbs and pelvic floor were treated with electrical stimulation, and drug therapy group was treated with Triamcinolone Acetonide Cream. Symptom and sign scores and quality of life index scores before treatment and 1, 3, 6, and 12 months after treatment were compared between two groups, and the occurrence of adverse reactions was observed. Results The symptom scores of physical therapy group were lower than those of drug therapy group at 12 months after treatment (P < 0.05). Sign scores of physical therapy group were higher than those of drug therapy group at 1 month after treatment (P < 0.05). The quality of life scores of physical therapy group were lower than those of drug therapy group at 1 and 6 months after treatment (P < 0.05). Sexual life scores of physical therapy group were lower than those of drug therapy group at 3,6, and 12 months after treatment (P < 0.05). The sleep anxiety scores of physical therapy group were lower than those of drug therapy group at 1, 6 and 12 months after treatment (P < 0.05). In the physical therapy group, one patient with diabetes developed vulvovaginal candidiasis, which was cured after treatment and continued treatment; in drug therapy group, two patients had local itching aggravation, prickling, redness, and swelling, and stopped taking the medicine. In the long-term medication follow-up, five patients showed unalleviated pruritus, local vascular dilation, pigmentation, and adverse drug reactions, and drug withdrawal. Conclusion Vascular smooth muscle electrical stimulation is safe and effective in the treatment of vulvar lichen sclerosus with few side effects. It has advantages in improving sexual life quality, skin pigment, and sleep anxiety recovery.
Key wordsVascular smooth muscle electrical stimulation    Triamcinolone acetonide    Vulvar lichen sclerosus    Quality of life
    
基金资助:国家自然科学基金地区科学基金项目(81960463)。
通讯作者: 马俊旗(1969.8-),女,硕士,主任医师,教授;研究方向:盆底疾病。   
作者简介: 刘念(1985.12-),女,硕士;研究方向:盆底疾病。
引用本文:   
刘念1 赵骏达1 刘娅2 马俊旗1. 平滑肌电刺激与曲安奈德治疗外阴硬化性苔藓的临床效果[J]. 中国医药导报, 2022, 19(15): 105-108.
LIU Nian1 ZHAO Junda1 LIU Ya2 MA Junqi1. Clinical effect of vascular smooth muscle electrical stimulation and triamcinolone acetonide of the patients with vulvar lichen sclerosus. 中国医药导报, 2022, 19(15): 105-108.
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https://www.yiyaodaobao.com.cn/CN/     或     https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I15/105

 

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