Progress in clinical application of event-related potentials in early onset schizophrenia
LIU Zhiwei1 YAO Gaofeng1 YANG Rongchun1 LIU Yun1 LIU Huanzhong2
1.Department of Psychiatry, Fuyang Third People’s Hospital, Anhui Province, Fuyang 236015, China;
2.Department of Psychiatry, Chaohu Hospital Affiliated to Anhui Medical University, Anhui Province, Chaohu 238000, China
Abstract:Early onset schizophrenia (EOS) refers to schizophrenia that develops before 18 years of age, and its clinical severity and prognosis are different from adult schizophrenia. As an effective neuroelectrophysiological marker, event-related potentials (ERPs) show great application prospect in patients with schizophrenia. In this paper, P300, mismatch negativity (MMN), N100, and other common components of ERPs are reviewed to explore their clinical application value in EOS patients. It was found that ERPs can be an ideal biological marker for EOS patients, which can help provide appropriate personalized interventions for the early stage of the disease. It provides some reference value for clinical practice to improve the prognosis of this disease.
刘志伟1 姚高峰1 杨荣春1 刘云1 刘寰忠2. 事件相关电位在早发精神分裂症中的临床应用进展[J]. 中国医药导报, 2022, 19(15): 53-56.
LIU Zhiwei1 YAO Gaofeng1 YANG Rongchun1 LIU Yun1 LIU Huanzhong2. Progress in clinical application of event-related potentials in early onset schizophrenia. 中国医药导报, 2022, 19(15): 53-56.
[1] Remschmidt H,Theisen F. Early-onset schizophrenia [J]. Neuropsychobiology,2012,66(1):63-69.
[2] Driver DI,Thomas S,Gogtay N,et al. Childhood-Onset Schizophrenia and Early-onset Schizophrenia Spectrum Disorders:An Update [J]. Child Adolesc Psychiatr Clin N Am,2020,29(1):71-90.
[3] 熊燕兵,任燕,崔晓红,等.早发精神分裂症静息态脑功能低频振幅研究[J].中国神经精神疾病杂志,2016,42(5):272-276.
[4] Helfrich RF,Knight RT. Cognitive neurophysiology:Event-related potentials [J]. Handb Clin Neurol,2019,160:543-558.
[5] 蒋凯,王丹,陈敏,等.慢性精神分裂症患者关联性负变波幅与认知功能的关系[J].中国神经精神疾病杂志,2020, 46(7):405-407.
[6] Lho SK,Kim M,Lee TH,et al. Predicting prognosis in patients with first-episode psychosis using auditory P300:A 1-year follow-up study [J]. Clin Neurophysiol,2019, 130(1):46-54.
[7] 彭焱,陈允恩,程淑英,等.慢性精神分裂症事件相关电位P300与精神症状的相关性研究[C]//Information Engineering Research Institute. Proceedings of 2014 4th International Conference on Applied Social Science(ICASS 2014)Volume 53. Singapore,2014:419-423.
[8] Devrim-?譈?觭ok M,Keskin-Ergen Y,?譈?觭ok A. Lack of progressive reduction in P3 amplitude after the first-episode of schizophrenia:A 6-year follow-up study [J]. Psychiatry Res,2016,243:303-311.
[9] Graber K,Bosquet Enlow M,Duffy FH,et al. P300 amplitude attenuation in high risk and early onset psychosis youth [J]. Schizophr Res,2019,210:228-238.
[10] Perlman G,Foti D,Jackson F,et al. Clinical significance of auditory target P300 subcomponents in psychosis:Differential diagnosis,symptom profiles,and course [J]. Schi-zophr Res,2015,165(2/3):145-151.
[11] Monaghan CK,Brickman S,Huynh P,et al. A longitudinal study of event related potentials and correlations with psychosocial functioning and clinical features in first episode psychosis patients [J]. Int J Psychophysiol,2019, 145:48-56.
[12] 赵旻骅,盛建军,王继军.精神分裂症语言加工缺陷事件相关电位研究进展[J].中国神经精神疾病杂志,2017, 10(43):59-61.
[13] Wang J,Liu Q,Wydell TN,et al. Electrophysiological basis of reading related phonological impairment in Chinese speakers with schizophrenia:An ERP study [J]. Psychiatry Res Neuroimaging,2017,261:65-71.
[14] Kim M,Lee TY,Lee S,et al. Auditory P300 as a predictor of short-term prognosis in subjects at clinical high risk for psychosis [J]. Schizophr Res,2015,165(2/3):138-144.
[15] Corcoran CM,Stoops A,Lee M,et al. Developmental trajectory of mismatch negativity and visual event-related potentials in healthy controls:Implications for neurodevelopmental vs. neurodegenerative models of schizophrenia [J]. Schizophr Res,2018,191:101-108.
[16] Rydkj?覸r J,M?覬llegaard Jepsen JR,Pagsberg AK,et al. Mismatch negativity and P3a amplitude in young adolescents with first-episode psychosis:a comparison with ADHD [J]. Psychol Med,2017,47(2):377-388.
[17] Koshiyama D,Kirihara K,Tada M,et al. Association between mismatch negativity and global functioning is specific to duration deviance in early stages of psychosis [J]. Schizophr Res,2018,195:378-384.
[18] Lepock JR,Mizrahi R,Korostil M,et al. Event-Related Potentials in the Clinical High-Risk(CHR)State for Psychosis:A Systematic Review [J]. Clin EEG Neurosci,2018,49(4):215-225.
[19] Kim M,Cho KI,Yoon YB,et al. Aberrant temporal behavior of mismatch negativity generators in schizophrenia patients and subjects at clinical high risk for psychosis [J]. Clin Neurophysiol,2017,128(2):331-339.
[20] Frost JD,Winkler I,Provost A,et al. Surprising sequential effects on MMN [J]. Biol Psychol,2016,116:47-56.
[21] Nagai T,Kirihara K,Tada M,et al. Reduced Mismatch Negativity is Associated with Increased Plasma Level of Glutamate in First-episode Psychosis [J]. Sci Rep,2017, 7(1):2258.
[22] Gonzalez-Heydrich J,Bosquet Enlow M,D’angelo E,et al. Early auditory processing evoked potentials(N100)show a continuum of blunting from clinical high risk to psychosis in a pediatric sample [J]. Schizophr Res,2015, 169(1/3):340-345.
[23] Fuerst DR,Gallinat J,Boutros NN. Range of sensory gating values and test-retest reliability in normal subjects [J]. Psychophysiol,2007,44(4):620-626.
[24] Rentzsch J,Jockers-Scherübl MC,Boutros NN,et al. Test-retest reliability of P50,N100 and P200 auditory sensory gating in healthy subjects [J]. Int J Psychophysiol,2008, 67(2):81-90.
[25] Rosburg T. Auditory N100 gating in patients with schizo-phrenia:A systematic meta-analysis [J]. Clin Neurophysiol,2018,129(10):2099-2111.
[26] Gonzalez-Heydrich J,Enlow MB,D’angelo E,et al. N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth [J]. Neural Plast,2016,2016:4209831.
[27] Mathalon DH,Roach BJ,Ferri JM,et al. Deficient auditory predictive coding during vocalization in the psychosis risk syndrome and in early illness schizophrenia:the final expanded sample [J]. Psychol Med,2019,49(11):1897-1904.
[28] Xu Y,Chai H,Zhang B,et al. Event-related potentials elicited by the Deutsch“high-low”word illusion in the patients with first-episode schizophrenia with auditory hallucinations [J]. BMC Psychiatry,2016,16:33.
[29] Arkhipov AY,Strelets VB. Neurophysiological Features of Perception of Emotional Stimuli in Health and in Patients with Paranoid Schizophrenia [J]. Fiziol Cheloveka,2015,41(4):31-36.
[30] Strelets VB,Arhipov AY,Garakh ZHV. Latencies of Sensory and Cognitive Components of Event Related Potentials during Perception of Verbal Stimuli in the Norm and Schizophrenic Patients [J]. Zh Vyssh Nerv Deiat Im I P Pavlova,2015,65(4):400-409.
[31] Garakh ZV,Zaytseva YS,Novototsky-Vlasov VY,et al. Perception of Verbal Stimuli in the Norm and in Schizophrenia [J]. Zh Vyssh Nerv Deiat Im I P Pavlova,2017,67(1):68-82.
[32] Gong J,Liu J,Shangguan L,et al. Childhood maltreatment impacts the early stage of facial emotion processing in young adults with negative schizotypy [J]. Neuropsychol,2019,134:107215.
[33] Earls HA,Curran T,Mittal V. Deficits in Early Stages of Face Processing in Schizophrenia:A Systematic Review of the P100 Component [J]. Schizophr Bull,2016,42(2):519-527.
[34] Sumich A,Harris A,Whitford T,et al. Neurophysiological correlates of excitement in men with recent-onset psychosis [J]. Psychiatr Danub,2018,30(1):64-71.
[35] Lee YJ,Jeong MY,Park S,et al. Age-Related Changes in Auditory Nogo-N200 Latency in Medication-Na?觙ve Children and Adolescents with Attention-Deficit / Hyperactivity Disorder [J]. Psychiatry Investig,2020,17(7):702-709.
[36] Magnuson JR,Iarocci G,Doesburg SM,et al. Increased Intra-Subject Variability of Reaction Times and Single-Trial Event-Related Potential Components in Children With Autism Spectrum Disorder [J]. Autism Res,2020, 13(2):221-229.
[37] ?覫ie MG,Sundet K,Haug E,et al. Cognitive Performance in Early-Onset Schizophrenia and Attention-Deficit / Hyperactivity Disorder:A 25-Year Follow-Up Study [J]. Front Psychol,2020,11:606365.
[38] 凌文琪,崔永华,郑毅.事件相关电位在儿童精神分裂症早期识别中的作用[J].中华行为医学与脑科学杂志,2018,27(5):476-480.