Abstract:Objective To analyze the failure factors of vaginal delivery in women with re-pregnancy with scar uterus. Methods The clinical data of 246 pregnant women with a history of cesarean scar uterus who gave birth in Huaibei Maternal and Child Health Hospital of Anhui Province from December 2018 to April 2021 were retrospectively analyzed. The results of trial production through vaginal delivery were counted and divided into a successful trial production group (198 cases) and a trial production failure group (48 cases). The clinical data of puerperae of the two groups were compared, the influencing factors of the failure of vaginal delivery in women with re-pregnancy with scar uterus were explored, and the predictive value of the failure of trial of vaginal delivery in women with re-pregnancy with scar uterus was evaluated. Results In this study, the failure rate of vaginal delivery in women with re-pregnancy with scar uterus was 19.51%. Body mass index (BMI) before labor and the proportions of pregnancy complications in the failed trial production group were higher than those in the successful trial production group, and the differences were statistically significant (P < 0.05). The thickness of the lower uterine segment myometrium and the Bishop score of the cervix before labor in the failed trial production group were lower than those in the successful trial production group, and the differences were statistically significant (P < 0.05). The results of logistic regression analysis showed that BMI before labor, thickness of lower uterine segment myometrium, and Bishop score of cervix before labor were the related factors affecting the failure of vaginal delivery in women with re-pregnancy with scar uterus (OR = 3.688, 2.878, 3.983, P < 0.05). ROC curve analysis showed that the best cut-off points of pre-partum BMI, lower uterine segment myometrial thickness and Bishop score of the cervix before labur for predicting the failure of vaginal delivery in women with re-pregnancy with scar uterus were 27.85 kg/m2, 2.21 mm, and 6.92 points, respectively; whie the AUCs were 0.619, 0.733, and 0.777, respectively. Conclusion Pre-labor BMI, lower uterine segment myometrial thickness and pre-labor cervix Bishop score can be used as important reference indicators for predicting the failure of vaginal delivery in these patients.
李奕 晋兴林 蒋玉芬. 瘢痕子宫再次妊娠产妇经阴道分娩试产失败因素分析[J]. 中国医药导报, 2022, 19(14): 28-31.
LI Yi JIN Xinglin JIANG Yufen. Analysis of failure factors of vaginal delivery in women with re-pregnancy with scar uterus. 中国医药导报, 2022, 19(14): 28-31.
[1] Martucci JL. Cesarean Section:An American History of Risk,Technology,and Consequence,by Jacqueline H. Wolf [J]. Nurs Hist Rev,2019,28(1):235-237.
[2] Bergholt T,Skjeldestad FE,Pyykonen A,et al. Maternal age and risk of cesarean section in women with induced labor at term-A Nordic register-based study [J]. Acta Obstet Gynecol Scand,2020,99(2):283-289.
[3] 赖文君,廖绮琳,陈梅英.疤痕子宫再次妊娠经阴道分娩的相关因素分析[J].中国病案,2018,19(6):86-88.
[4] 黄丽慧,杨益民.COOK水囊在瘢痕子宫足月妊娠阴道分娩中的应用[J].中国妇幼健康研究,2018,15(1):96-99.
[5] 郭长红,元玥,高用娟.剖宫产术后瘢痕子宫再次妊娠经阴道分娩影响因素分析[J].临床军医杂志,2018,46(8):950-951,953.
[6] 曹泽毅.中华妇产科学[M].北京:人民卫生出版社,2014:58-62.
[7] Laughon SK,Zhang J,Troendle J,et al. Using a simplified Bishop score to predict vaginal delivery [J]. Obstet Gynecol,2011,117(4):805-811.
[8] Vallikkannu N,Lam WK,Omar SZ,et al. Insulin-like growth factor binding protein 1,Bishop score,and sonographic cervical length:tolerability and prediction of vaginal birth and vaginal birth within 24 hours following labour induction in nulliparous women [J]. BJOG,2017,124(8):1274-1283.
[9] Fonseca JE,Rodriguez JL,Maya SD. Validation of a predictive model for successful vaginal birth after cesarean section [J]. Colomb Med (Cali),2019,50(1):13-21.
[10] Mariani GL,Vain NE. The rising incidence and impact of non-medically indicated pre-labour cesarean section in Latin America [J]. Semin Fetal Neonatal Med,2019, 24(1):11-17.
[11] 郑娟,侯祎.剖宫产后瘢痕子宫再次妊娠分娩方式的临床选择及安全性分析[J].中国妇幼保健,2019,34(7):1470-1472.
[12] 吴兆晴,徐金霞.剖宫产后瘢痕子宫再次妊娠阴道分娩孕妇的妊娠结局分析[J].中国妇产科临床杂志,2019, 20(3):61-62.
[13] 梅金凤,范荷花,杨丽娟.宫腔镜治疗子宫瘢痕憩室患者不良预后的影响因素分析[J].中国当代医药,2021, 28(15):123-125,135.
[14] Hua Z,El OF. Indicators for mode of delivery in pregnant women with uteruses scarred by prior caesarean section:a retrospective study of 679 pregnant women [J]. BMC Pregnancy Childbirth,2019,19(1):445.
[15] Ryan GA,Nicholson SM,Morrison JJ. Vaginal birth after caesarean section:Current status and where to from here? [J]. Eur J Obstet Gynecol Reprod Biol,2018,224(63):52-57.
[16] 梁欣.剖宫产术后瘢痕子宫再次妊娠阴道试产失败危险因素Logistic回归分析[J].检验医学与临床,2017,14(24):3693-3695.
[17] 黄翠莲,吴璇华,赖冬梅.瘢痕子宫再次妊娠分娩时机和分娩方式选择的影响因素分析[J].国际妇产科学杂志,2018,45(5):82-85.
[18] Machado JL,Fama E,Zamboni JW,et al. Risk score for failed trial of vaginal birth after a previous cesarean section including data of labor course [J]. J Obstet Gynaecol Res,2020,46(1):93-103.
[19] 赖冬梅.瘢痕子宫再次妊娠采取阴道分娩的成功率及安全性分析[J].四川医学,2018,39(8):921-925.
[20] Paquette K,Markey S,Roberge S,et al. First and Third Trimester Uterine Scar Thickness in Women With Previous Caesarean:A Prospective Comparative Study [J]. J Obstet Gynaecol Can,2019,41(1):59-63.
[21] 曾容.剖宫产术后子宫下段菲薄瘢痕子宫孕妇阴道分娩的可行性分析[J].中国妇幼保健,2018,33(1):19-21.
[22] Spiegel E,Weintraub AY,Aricha-Tamir B,et al. The use of sonographic myometrial thickness measurements for the prediction of time from induction of labor to delivery [J]. Arch Gynecol Obstet,2021,303(4):891-896.
[23] 陈淑华,钟诚.瘢痕子宫下段肌层厚度与阴道试产失败的关系[J].中国性科学,2020,249(10):108-111.
[24] Eleje GU,Ezugwu EC,Ugwu EO,et al. Premaquick versus modified Bishop score for preinduction cervical assessment at term:A double-blind randomized trial [J]. J Obstet Gynaecol Res,2018,44(8):1404-1414.
[25] 高良菊.剖宫产术后瘢痕子宫再次妊娠经阴道分娩影响因素分析[J].医药前沿,2020,10(4):104-105.
[26] Alanwar A,Hussein SH,Allam HA,et al. Transvaginal sonographic measurement of cervical length versus Bishop score in labor induction at term for prediction of caesarean delivery [J]. J Matern Fetal Neonatal Med,2021, 34(13):2146-2153.