Correlation between diffusion weighted imaging, dynamic enhanced MRI parameters and Ki67 expression in breast cancer#br#
LI Ji1 ZHANG Jiawei1 PENG Fei1 YANG Shulan2 LI Dandan3
1.Magnatic Resonance Imaging Room, Tangshans People’s Hospital, Hebei Province, Tangshan 063000, China;
2.Department of Radiology, Tangshan Maternal and Children Health Hospital, Heibei Province, Tangshan 063000, China;
3.Department of Pathology, Tangshan Union Medical College Hospital, Heibei Province, Tangshan 063000, China
Abstract：Objective To investigate the correlation between diffusion weighted imaging (DWI), dynamic enhanced MRI (DCE-MRI) parameters and the expression level of Ki67 in breast cancer. Methods A total of 95 patients who were first diagnosed with breast cancer in Tangshan People’s Hospital of Hebei Province from January to December 2020 were collected and divided into grade Ⅰ group (38 cases), grade Ⅱ group (42 cases), and grade Ⅲ group (15 cases) according to breast cancer classification. According to the expression level of Ki67, they were divided into low expression group (40 cases), medium expression group (40 cases), and high expression group (15 cases). General data, DWI(apparent dispersion coefficient [ADC]) and DCE-MRI parameters (time to peak of contrast agent concentration [TTP], peak enhancement [SImax], early enhancement rate [EER]) were compared. Spearman correlation coefficient was used to analyze the correlation between ADC, TTP, SImax, EER, and Ki67 expression levels. Results ADC, TTP, and SImax of grade Ⅱ and Ⅲ groups were lower than those of grade Ⅰ group, and EER was higher than that of grade Ⅰ group; ADC, TTP, and SImax of grade Ⅲ group were lower than those of grade Ⅱ group, and EER was higher than that of grade Ⅱ group, the differences were statistically significant (P ＜ 0.05). ADC, TTP, and SImax in medium and high expression groups were lower than those in low expression group, and EER was higher than that in low expression group; ADC, TTP, and SImax in high expression group were lower than those in medium expression group, and EER was higher than that in medium expression group, the differences were statistically significant (P ＜ 0.05). Correlation analysis showed that ADC, TTP, and SImax were negatively correlated with Ki67 expression (r ＜ 0, P ＜ 0.05), and EER was positively correlated with Ki67 expression (r ＞ 0, P ＜ 0.05). Conclusion DWI and DCE-MRI parameters are correlated with Ki67 expression in breast cancer, which provided certain reference for selecting reasonable treatment plan and prognosis in the future.
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