C反应蛋白基因多态性与肿瘤发生发展关系的研究进展

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摘要人类C反应蛋白（CRP）的基线水平以CRP基因中存在的单核苷酸多态性影响最为显著并具有个体差异，近年来流行病学和研究发现CRP基因中的遗传多态性所致的CRP水平升高与癌症风险增加，肿瘤的增殖、转移及不良预后等密切相关。此外，基因组上一些相关参与调控CRP水平的单核苷酸多态性位点不断被发现并具有相同的功能。但一些研究发现遗传性升高的CRP水平与癌症发生并无因果关系。目前认为这些差异可能与不同的种族、地域、样本量、环境和遗传因素等有关。本文对CRP基因多态性与肿瘤发生发展之间的研究进展作一综述，以期为探讨CRP基因多态性与肿瘤免疫相关病因学途径的发病机制研究提供参考。

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	任珊1* 任敏玮2* 戴文斌3

关键词 ： C反应蛋白, 基因多态性, 单核苷酸多态性, 肿瘤, 发生发展

Abstract：The baseline level of human C-reactive protein (CRP) is most significant influenced by single nucleotide polymorphism in CRP gene and has individual differences. In recent years, epidemiology and research have found that the increased CRP level caused by genetic polymorphism in CRP gene is closely related to the increased risk of cancer and the proliferation and metastasis of tumors and poor prognosis. In addition, a number of genome-wide single nucleotide polymorphisms that are involved in the regulation of CRP levels are being identified and have similar functions. But some studies have found no causal relationship between genetically elevated CRP levels and cancer. It is believed that these differences may be related to different races, regions, sample sizes, environmental factors and genetic factors. This article reviews the research progress of CRP gene polymorphism and tumorigenesis and development, in order to provide reference for the study of the pathogenesis of CRP gene polymorphism and tumor immune-related etiology pathway.

Key words： C-reactive protein Gene polymorphism Single nucleotide polymorphism Tumour Ogenesis and development

基金资助:广西壮族自治区卫生健康委员会自筹经费科研课题（Z20200154）；
广西自然科学基金资助项目（桂科自0991270）。

通讯作者: 戴文斌（1973-），男，硕士，主任医师；研究方向：肿瘤病理。

作者简介: 任珊（1982-），女，硕士，副主任技师，主要从事肝癌遗传易感性的研究。 *具有同等贡献

引用本文:

任珊1* 任敏玮2* 戴文斌3. C反应蛋白基因多态性与肿瘤发生发展关系的研究进展[J]. 中国医药导报, 2022, 19(13): 59-63.
REN Shan1* REN Minwei2* DAI Wenbin3. Research progress on the relationship between C-reactive protein gene polymorphism and tumorigenesis and development#br#. 中国医药导报, 2022, 19(13): 59-63.

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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I13/59

[1] Polterauer S，Grimm C，Zeillinger R，et al. Association of C-reactive protein（CRP）gene polymorphisms，serum CRP levels and cervical cancer prognosis [J]. Anticancer Res，2011，31（6）：2259-2264.
[2] Madi A，Cui G. Regulation of immune cell metabolism by cancer cell oncogenic mutations [J]. Int J Cancer，2020， 147（2）：307-316.
[3] Meirow Y，Baniyash M. Immune biomarkers for chronic inflammation related complications in non cancerous and cancerous diseases [J]. Cancer Immunol Immunother，2017， 66（8）：1089-1101.
[4] Rajab IM，Hart PC，Potempa LA. How C-Reactive Protein Structural Isoforms With Distinctive Bioactivities Affect Disease Progression [J]. Front Immunol，2020，11：2126.
[5] Potempa LA，Rajab IM，Olson ME，et al. C-Reactive Protein and Cancer： Interpreting the Differential Bioactivities of Its Pentameric and Monomeric，Modified Isoforms [J]. Front Immunol，2021，12：744129.
[6] Singh SK，Agrawal A. Functionality of C-Reactive Protein for Atheroprotection [J]. Front Immunol，2019，10：1655.
[7] McFadyen JD，Zeller J，Potempa LA，et al. C-Reactive Protein and Its Structural Isoforms：An Evolutionary Conserved Marker and Central Player in Inflammatory Diseases and Beyond [J]. Subcell Biochem，2020，94：499-520.
[8] Best LG，Balakrishnan P，Cole SA，et al. Genetic analysis of hsCRP in American Indians：The Strong Heart Family Study [J]. PLoS One，2019，14（10）：e0223574.
[9] Arouca AB，Meirhaeghe A，Dallongeville J，et al. Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents [J]. Clin Nutr，2020，39（6）：1919-1926.
[10] Ligthart S，Vaez A，V?觛sa U，et al. Genome Analyses of >200，000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders [J]. Am J Hum Genet，2018， 103（5）：691-706.
[11] Prasad G，Giri AK，Basu A，et al. Genomewide association studyfor C-reactive protein in Indians replicates known associations of common variants [J]. J Genet，2019， 98：20.
[12] Reynoso-Villalpando GL，Casillas-Mu?觡oz FA，Padilla-Gutiérrez JR，et al. The Genetic Variants -717T>C （rs2794521），1444G>A （rs1130864），and 1846C > T （rs1205） of CRP Gene，Their Haplotypes，and Their Association with Serum CRP Levels，Acute Coronary Syndrome，and Diabetes in Patients from Western Mexico [J]. Metab Syndr Relat Disord，2021，19（3）：127-136.
[13] Kocarnik JM，Richard M，Graff M，et al. Discovery，fine-mapping，and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology （PAGE）study [J]. Hum Mol Genet，2018，27（16）：2940-2953.
[14] Jung SY，Scott PA，Papp JC，et al. Genome-wide Association Analysis of Proinflammatory Cytokines and Gene-lifestyle Interaction for Invasive Breast Cancer Risk：The WHI dbGaP Study [J]. Cancer Prev Res（Phila），2021，14（1）：41-54.
[15] Hart PC，Rajab IM，Alebraheem M，et al. C-Reactive Protein and Cancer-Diagnostic and Therapeutic Insights [J]. Front Immunol，2020，11：595835.
[16] Geng P，Sa R，Li J，et al. Genetic polymorphisms in C-reactive protein increase cancer susceptibility [J]. Sci Rep，2016，6：17161.
[17] Pan HY，Mi YY，Xu K，et al. Association of C-resctive protein（CRP）rs1205 and rs2808630 variants and risk of cancer [J]. J Cell Physiol，2020，235（11）：8571-8584.
[18] Chen C，Liu JN，Zhao JQ，et al. C-reactive protein gene 1846C>T polymorphism is associated with increased risk and clinical features of lung cancer：a case-control study [J]. Biosci Rep，2019，39（6）：BSR20181936.
[19] Jung SY，Yu H，Pellegrini M，et al. Genetically determined elevated C-reactive protein associated with primary colorectal cancer risk： Mendelian randomization with lifestyle interactions [J]. Am J Cancer Res，2021，11（4）：1733-1753.
[20] Jung SY，Papp JC，Sobel EM，et al. Genetically Predicted C-Reactive Protein Associated With Postmenopausal Breast Cancer Risk：Interrelation With Estrogen and Cancer Molecular Subtypes Using Mendelian Randomization [J]. Front Oncol，2020，10：630994.
[21] Lao X，Ren S，Lu Y，et al. Genetic polymorphisms of C-reactive protein increase susceptibility to HBV-related hepatocellular carcinoma in a Guangxi male population [J]. Int J Clin Exp Pathol，2015，8（12）：16055-16063.
[22] Motoyama S，Nakatsu T，Miura M，et al. A CRP genetic polymorphism associated with the tumoral expression of CRP in esophageal cancer [J]. Surg Today，2013，43（3）：339-340.
[23] Terata K，Motoyama S，Kamata S，et al. Evaluation of the potential for lymph node metastasis using CRP 1846C>T genetic polymorphism in invasive breast cancer [J]. Tumour Biol，2014，35（6）：5931-5935.
[24] Huang CJ，Teng，HW，Chien CC，et al. Prognostic significance of C-reactive protein polymorphism and KRAS/BRAF in synchronous liver metastasis from colorectal cancer [J]. PLoS One，2013 ，8（6）：e65117.
[25] Kito M，Motoyama S，Fujita K，et al. CRP 1846C>T Genetic Polymorphism Is Associated with Lymph Node Metastasis and/or Severe Lymphatic Invasion in Endometrial Cancer [J]. Tohoku J Exp Med，2015，237（1）：25-30.
[26] Wang X，Dai JY，Albanes D，et al. Mendelian randomization analysis of C-reactive protein on colorectal cancer risk [J]. Int J Epidemiol，2019，48（3）：767-780.
[27] Wang MY，Zhou HH，Zhang CH，et al. A Functional Genetic Variant at the C-Reactive Protein Promoter （rs3091244）Is Not Associated With Cancer Risk in a Chinese Population [J]. Front Immunol，2020，11：926.
[28] Zhou DJ，Bai FJ. The relationship between C-reactive protein gene +1444C/T，3407T/C polymorphisms and colorectal cancer susceptibility [J]. Gene，2019，710：145-147.
[29] Jung SY，Papp JC，Sobel EM，et al. Pro-inflammatory cytokine polymorphisms in ONECUT2 and HNF4A and primary colorectal carcinoma: a post genome-wide gene-lifestyle interaction study [J]. Am J Cancer Res，2020，10（9）：2955-2976.