Research progress on acquired immune deficiency syndrome patients with depression#br#
HUANG Mingyan1 DING Xue2 MA Xiuxia2 MENG Pengfei2 GUO Jiale1 ZHONG Pengzhan1 CAI Xiaoyang1 XU Liran2
1.The First Clinical Medical College, Henan University of Traditional Chinese Medicine, Henan Province, Zhengzhou 450000, China;
2.AIDS Clinical Research Center, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Henan Province, Zhengzhou 450000, China
Abstract:In the course of long-term highly active anti-retroviral therapy (HAART), acquired immune deficiency syndrome (AIDS) patients can easily lead to depression due to physiological and psychological reasons. Depression can also reduce the compliance of HAART, affect the HAART effect, and the quality of life. The occurrence of depression in AIDS patients is related to general factors such as gender, economic level, and education level, psychological factors, social support, and AIDS related factors. The treatment of AIDS patients with depression must be carried out simultaneously with HAART. For mild depression, comprehensive therapy such as psychotherapy and traditional Chinese medicine can be used. Moderate and above depression should be treated with antidepressants. This paper reviews the related research progress of AIDS complicated with depression, in order to provide reference for the clinical diagnosis and treatment of AIDS complicated with depression.
[1] Tran BX,Ho RCM,Ho CSH,et al. Depression among Patients with HIV/AIDS:Research Development and Effective Interventions(GAPRESEARCH)[J]. Int J Environ Res Public Health,2019,16(10):1772.
[2] Chibanda D. Depression and HIV:integrated care towards 90-90-90 [J]. Int Health,2017,9(2):77-79.
[3] Uthman OA,Magidson JF,Safren SA,et al. Depression and adherence to antiretroviral therapy in low-,middle-and high-income countries:a systematic review and meta-analysis [J]. Curr HIV/AIDS Rep,2014,11(3):291-307.
[4] 袁清青,李芙蓉,阮艺宏,等.中国艾滋病患者群体中抑郁症患病率Meta分析[J].中国艾滋病性病,2021,27(1):45-49.
[5] Bhatia MS,Munjal S. Prevalence of Depression in People Living with HIV/AIDS Undergoing ART and Factors Associated with it [J]. J Clin Diagn Res,2014,8(10):WC1-WC4.
[6] Junaid K,Ali H,Khan AA,et al. Prevalence and Associated Factors of Depression among Patients with HIV/AIDS in Lahore,Pakistan:Cross-Sectional Study [J]. Psychol Res Behav Manag,2021,14:77-84.
[7] Rezaei S,Ahmadi S,Rahmati J,et al. Global prevalence of depression in HIV/AIDS:a systematic review and meta-analysis [J]. BMJ Support Palliat Care,2019,9(4):404-412.
[8] Rane MS,Hong T,Govere S,et al. Depression and Anxiety as Risk Factors for Delayed Care-Seeking Behavior in Human Immunodeficiency Virus-Infected Individuals in South Africa [J]. Clin Infect Dis,2018,67(9):1411-1418.
[9] Adams LM,Wilson TE,Merenstein D,et al. Using the Center for Epidemiologic Studies Depression Scale to assess depression in women with HIV and women at risk for HIV:Are somatic items invariant?[J]. Psychol Assess,2018,30(1):97-105.
[10] Medeiros GC,Smith FA,Trivedi MH,et al. Depressive Disorders in HIV/AIDS:A Clinically Focused Narrative Review [J]. Harv Rev Psychiatry,2020,28(3):146-158.
[11] 李宵,刘洁.HIV感染者/AIDS患者抑郁研究进展[J].现代预防医学,2019,46(23):4368-4371.
[12] Swendeman D,Fehrenbacher AE,Roy S,et al. Gender disparities in depression severity and coping among people living with HIV/AIDS in Kolkata,India [J]. PLoS One,2018,13(11):e0207055.
[13] 陈学军,李敏,张丹,等.基层医院接受抗病毒治疗人类免疫缺陷病毒感染者抑郁焦虑状况及影响因素分析[J].实用医院临床杂志,2020,17(3):136-139.
[14] Familiar I,Murray S,Ruisenor-Escudero H,et al. Socio-demographic correlates of depression and anxiety among female caregivers living with HIV in rural Uganda [J]. AIDS Care,2016,28(12):1541-1545.
[15] Duko B,Geja E,Zewude M,et al. Prevalence and associated factors of depression among patients with HIV/AIDS in Hawassa,Ethiopia,cross-sectional study [J]. Ann Gen Psychiatry,2018,17:45.
[16] 邵永惠,刘亚文,薛痕,等.不同告知方式对HIV/AIDS焦虑抑郁情绪及遵医行为的影响[J].预防医学情报杂志,2019,35(10):1108-1112.
[17] Beyene Gebrezgiabher B,Huluf Abraha T,Hailu E,et al. Depression among Adult HIV/AIDS Patients Attending ART Clinics at Aksum Town,Aksum,Ethiopia:A Cross-Sectional Study [J]. Depress Res Treat,2019,2019:3250431.
[18] Leonard BE. The concept of depression as a dysfunction of the immune system [J]. Curr Immunol Rev,2010,6(3):205-212.
[19] Del Guerra FB,Fonseca JL,Figueiredo VM,et al. Human immunodeficiency virus-associated depression:contributions of immuno-inflammatory,monoaminergic,neurodegenerative,and neurotrophic pathways [J]. J Neurovirol,2013,19(4):314-327.
[20] 李强,张晓伟,谢正,等.柴胡加龙骨牡蛎汤对艾滋病抑郁症患者临床症状及免疫功能的影响[J].辽宁中医杂志,2010,37(5):877-878.
[21] Shi Y,Yang C,Xu L,et al. CD4+ T Cell Count,Sleep,Depression,and Anxiety in People Living With HIV:A Growth Curve Mixture Modeling [J]. J Assoc Nurses AIDS Care,2020,31(5):535-543.
[22] Rooney AS,Moore RC,Paolillo EW,et al. Depression and aging with HIV:Associations with health-related quality of life and positive psychological factors [J]. J Affect Disord,2019,251:1-7.
[23] 周仲英.中医内科学[M].北京:中国中医药出版社,2007.
[24] AIDS Prevention and Treatment Branch of China Association of Chinese Medicine,中华中医药学会防治艾滋病分会,新疆维吾尔自治区中医医院,等.艾滋病相关焦虑中西医协同治疗专家共识[J].中医学报,2020,35(9):1889-1892.
[25] 张玉辉,庞允,梁鹏飞.扶正解郁汤对艾滋病后抑郁症患者免疫功能及抑郁程度的影响[J].湖北中医杂志,2020,42(10):13-15.
[26] 谢正,陈秀敏,李强,等.柴胡加龙骨牡蛎汤对艾滋病抑郁症患者免疫功能及生存质量的影响[J].时珍国医国药,2010,21(3):577-579.
[27] 王健,梁碧颜,闫世艳,等.中医药治疗8946例艾滋病患者临床观察[J].中医杂志,2011,52(5):395-398.
[28] 闫炳远.益艾康胶囊合逍遥散加减治疗艾滋病伴发焦虑抑郁临床观察[J].中国中西医结合杂志,2010,30(5):553-555.
[29] 曾海军.丹栀逍遥散配合心理干预治疗艾滋病抑郁症患者的临床效果[J].黑龙江中医药,2021,50(2):3-4.
[30] 舒云,蒋自强,张雪.针灸联合逍遥散加减治疗艾滋病抑郁症30例[J].中医研究,2016,29(8):68-70.
[31] 刘振威,庞军,姜枫,等.同伴教育模式下的艾灸疗法治疗HIV感染者负面情绪的临床观察[J].时珍国医国药,2018,29(1):136-137.
[32] 彭小雷,曹江鹏,苏伟,等.八段锦功法对艾滋病携带者的戒毒人员情志影响的初步观察[J].运动,2016(6):137-138.
[33] Nakimuli-Mpungu E,Wamala K,Okello J,et al. Group support psychotherapy for depression treatment in people with HIV/AIDS in northern Uganda:a single-centre randomised controlled trial [J]. Lancet HIV,2015,2(5):e190-e199.
[34] 谢红燕,陈鸿杰,李冰,等.正念减压训练对HIV感染者/AIDS患者焦虑、抑郁情绪及免疫功能的影响[J].中国护理管理,2019,19(7):1058-1063.
[35] 郑小燕,马琴,谈迎春,等.心理治疗及其延伸对艾滋病患者焦虑和抑郁的影响[J].国际精神病学杂志,2018, 45(2):364-366.
[36] 傅亮,吴密彬,胡雁.认知行为疗法对HIV感染者和AIDS患者抑郁、服药依从性和生活质量影响的系统评价[J].中国循证医学杂志,2014,14(6):734-742.
[37] Eshun-Wilson I,Siegfried N,Akena DH,et al. Antidepressants for depression in adults with HIV infection [J]. Cochrane Database Syst Rev,2018,1(1):CD008525.
[38] Ferrando SJ,Goldman JD,Charness WE. Selective serotonin reuptake inhibitor treatment of depression in symptomatic HIV infection and AIDS. Improvements in affective and somatic symptoms [J]. Gen Hosp Psychiatry,1997, 19(2):89-97.
[39] Rabkin JG,Rabkin R,Harrison W,et al. Effect of imipramine on mood and enumerative measures of immune status in depressed patients with HIV illness [J]. Am J Psychiatry,1994,151(4):516-523.
[40] Yanofski J,Croarkin P. Choosing Antidepressants for HIV and AIDS Patients:Insights on Safety and Side Effects [J]. Psychiatry(Edgmont),2008,5(5):61-66.
[41] Prasithsirikul W,Chongthawonsatid S,Ohata PJ,et al. Depression and anxiety were low amongst virally suppressed,long-term treated HIV-infected individuals enrolled in a public sector antiretroviral program in Thailand [J]. AIDS Care,2017,29(3):299-305.
[42] Tao J,Vermund SH,Qian HZ. Association Between Depression and Antiretroviral Therapy Use Among People Living with HIV:A Meta-analysis [J]. AIDS Behav,2018, 22(5):1542-1550.