Abstract：Objective To investigate the clinical effect of Yishen Juanbi Pills combined with Methotrexate Tablets in the treatment of rheumatoid arthritis (RA). Methods A total of 96 RA patients admitted to Baoding Second Central Hospital from April 2020 to May 2021 were selected and they were divided into control group and observation group according to random number table method, with 48 patients in each group. The control group was treated with Methotrexate Tablets, and the observation group was treated with Yishen Juanbi Pills on the basis of the control group for six months. Clinical efficacy, clinical symptoms, and adverse reactions were compared between the two groups, and serum C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF) titer, matrix metalloproteinase-1 (MMP-1), MMP-3, and anti streptolysin “O” (ASO) were detected and compared before and after six months of treatment. Results After six months of treatment, rest pain time, morning stiffness time, joint swelling number and joint tenderness index in both groups were lower than those before treatment, and those in the observation group was lower than those in the control group, the differences were statistically significant (P ＜ 0.05). After six months of treatment, the hand grip strength of both groups was increased compared with that before treatment, and that of observation group was higher than that of control group, the differences were statistically significant (P ＜ 0.05). After six months of treatment, CRP, ESR, RF, MMP-1, MMP-3, and ASO in both groups were lower than before treatment, and those in the observation group were lower than those in the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). After six months of treatment, the clinical effect of observation group was better than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion Yishen Juanbi Pills combined with Methotrexate Tablets has significant efficacy in the treatment of RA patients, which can effectively improve the clinical symptoms of patients and reduce the level of inflammatory factors, with good safety.
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