Abstract：Objective To explore the changes and clinical significance of urinary angiotensinogen (UAGT) and neutrophil gelatinase-associated lipocalin (NGAL) levels in hypertensive nephropathy. Methods A total of 130 hypertensive patients admitted to Yixing People’s Hospital, Jiangsu Province from March 2018 to March 2021 were selected. According to whether they had hypertensive nephropathy, they were divided into simple hypertension group (74 cases) and hypertensive nephropathy group (56 cases). The clinical data, UAGT, and NGAL levels of the two groups were compared. Logistic regression model was used to analyze the influencing factors of hypertensive nephropathy, and the diagnostic value of UAGT and NGAL levels in hypertensive nephropathy was analyzed by receiver operating characteristic curve. Results Levels of urinary microalbumin, serum creatinine, UAGT, and NGAL in hypertensive nephropathy group were higher than those in simple hypertension group, the differences were statistically significant (P ＜ 0.05). Multivariate analysis showed that UAGT, NGAL, and urinary microalbumin were independent influencing factors of hypertensive nephropathy (P ＜ 0.05). UAGT and NGAL had certain diagnostic value for hypertensive nephropathy, and the area under the curve was 0.862 and 0.869, respectively (P ＜ 0.05). Conclusion UAGT and NGAL levels are abnormally elevated in hypertensive nephropathy patients, and both of them are independent influencing factors of hypertensive nephropathy. Detection of changes in UAGT and NGAL levels can be used as sensitive indicators for evaluation of hypertensive nephropathy.
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