白细胞介素、脂联素基因多态性与乳腺癌发生的关系

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摘要目的探讨白细胞介素（IL）、脂联素（APN）基因多态性与乳腺癌发生的关系。方法本研究为回顾性分析，将2018年1月至2020年1月南通大学附属如皋医院（以下简称“我院”）收治的96例乳腺癌患者为乳腺癌组，另选我院96名同期体检正常女性作为正常对照组。统计两组一般资料，检测IL、APN基因多态性，分析女性乳腺癌发生的影响因素。结果两组IL-10基因启动子区-1082基因型、IL-16基因rs1556218基因型、IL-6基因-572基因型、IL-8基因-251基因型、APN基因-276基因型比较，差异有统计学意义（P ＜ 0.05）。IL-10基因启动子区-1082GA基因型、IL-16基因rs1556218TG基因型、IL-6基因-572CG基因型、IL-8基因-251TA基因型、APN基因-276TG基因型是女性乳腺癌发生的影响因素（P ＜ 0.05）。结论女性乳腺癌的发生与IL-10基因启动子区-1082 GA基因型、IL-16基因rs1556218 TG基因型、IL-6基因-572 CG基因型、IL-8基因-251 TA基因型、APN基因-276 TG基因型密切相关。

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	许伟马梓程周细华

关键词 ：白细胞介素, 脂联素, 乳腺癌, 基因多态性

Abstract：Objective To explore the relationship between interleukin (IL), adiponectin (APN) gene polymorphisms and breast cancer Methods This study was a retrospective analysis, a total of 96 patients with breast cancer admitted to Rugao Hospital Affiliated to Nantong University (“our hospital” for short) from January 2018 to January 2020 were divided into breast cancer group, another 96 healthy women in our hospital who received physical examination in the same period were selected as normal control group. The general data of two groups were collected, and the gene polymorphisms of IL and APN genes were detected, the influencing factors of female breast cancer were analyzed. Results There were statistically significant differences between two groups in IL-10 gene promoter region-1082 genotype, IL-16 gene rs1556218 genotype, IL-6 gene-572 genotype, IL-8 gene-251 genotype, and APN gene-276 genotype (P ＜ 0.05). IL-10 gene promoter region -1082 GA genotype, IL-16 gene rs1556218 TG genotype, IL-6 gene-572 CG genotype, IL-8 gene-251 TA genotype, and APN gene- 276TG genotype were influencing factors of female breast cancer (P < 0.05). Conclusion The occurrence of female breast cancer is closely related to IL-10 gene promoter region-1082 GA genotype, IL-16 gene rs1556218 TG genotype, IL-6 gene-572 CG genotype, IL-8 gene-251 TA genotype, and APN gene-276 TG genotype.

Key words： Interleukin Adiponectin Breast cancer Gene polymorphism

基金资助:江苏省研究生科研与实践创新计划项目（KYCX191243）。

作者简介: 许伟（1989.1-），男，硕士；研究方向：乳腺癌临床与发病机制的基础研究。

引用本文:

许伟马梓程周细华. 白细胞介素、脂联素基因多态性与乳腺癌发生的关系[J]. 中国医药导报, 2022, 19(11): 131-134.
XU Wei MA Zicheng ZHOU Xihua. Relationship between interleukin, adiponectin gene polymorphism and breast cancer#br#. 中国医药导报, 2022, 19(11): 131-134.

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