前列腺癌组织中LncRNA LINC00355、miR-494-3p、CCND2的表达及临床意义

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摘要目的探讨前列腺癌组织中长链非编码RNA（LncRNA）LINC00355、微小RNA-494-3p（miRNA-494-3p）、细胞周期素D2（CCND2）的表达及临床意义。方法选取安徽省第二人民医院2015年1月至2017年12月收治的91例前列腺癌患者，qRT-PCR检测患者癌组织和癌旁正常组织中LncRNA LINC00355、miR-494-3p、CCND2 mRNA表达。Kaplan-Meier曲线分析不同LncRNA LINC00355、miR-494-3p、CCND2 mRNA表达前列腺癌患者的术后3年生存率。结果前列腺癌组织中LncRNA LINC00355、CCND2 mRNA表达高于癌旁正常组织，miR-494-3p表达低于癌旁正常组织（P ＜ 0.05）。前列腺癌组织中LncRNA LINC00355与miR-494-3p表达呈负相关，与CCND2 mRNA表达呈正相关（r = -0.502、0.458，P ＜ 0.001），miR-494-3p与CCND2 mRNA表达呈负相关（r = -0.493，P ＜ 0.001）。LncRNA LINC00355高表达、miR-494-3p低表达、CCND2 mRNA高表达患者术后3年总生存率低于LncRNA LINC00355低表达、miR-494-3p高表达、CCND2 mRNA低表达患者（P ＜ 0.05）。结论前列腺癌组织中LncRNA LINC00355、CCND2表达上调，miR-494-3p表达下调，LncRNA LINC00355可能通过抑制miR-494-3p上调CCND2表达，促进前列腺癌进展。

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	解丹丹1 夏磊2 李松果1 潘献柱1

关键词 ：前列腺癌, 长链非编码RNA, LINC00355, 微小RNA-494-3p

Abstract：Objective To investigate the expression and clinical significance of long non-coding RNA (LncRNA) LINC00355, microRNA-494-3p (miRNA-494-3p), cyclin D2 (CCND2) mRNA expression in prostate cancer tissues. Methods A total of 91 prostate cancer patients admitted to Anhui NO.2 Provincial People’s Hospital from January 2015 to December 2017 were selected. qRT-PCR was used to detect the expression of LncRNA LINC00355, miR-494-3p, and CCND2 mRNA in cancer tissues and paracancer normal tissues of patients. Kaplan-Meier curve was used to analyze three-year survival rate after surgery of prostate cancers with different LncRNA LINC00355, miR-494-3p, and CCND2 mRNA expression. Results LncRNA LINC00355 and CCND2 mRNA expression in prostate cancer tissues were higher than those in paracancer normal tissues, and miR-494-3p expression was lower than that in paracancer normal tissues (P ＜ 0.05). LncRNA LINC00355 was negatively correlated with miR-494-3p expression and positively correlated with CCND2 mRNA expression in prostate cancer tissues (r = -0.502, 0.458, P ＜ 0.001), and miR-494-3p was negatively correlated with CCND2 mRNA expression (r = -0.493, P ＜ 0.001). The three-year overall survival rate after surgery in patients with high LncRNA LINC00355 expression, low miR-494-3p expression, and high CCND2 mRNA expression were lower than those in patients with low LncRNA LINC00355 expression, high miR-494-3p expression, and low CCND2 mRNA expression (P ＜ 0.05). Conclusion LncRNA LINC00355 and CCND2 expression are up-regulated and miR-494-3p expression is down-regulated in prostate cancer tissues. LncRNA LINC00355 may promote prostate cancer progression by inhibiting miR-494-3p and up-regulating CCND2 expression.

Key words： Prostate cancer Long non-coding RNA LINC00355 MicroRNA-494-3p

基金资助:安徽省高校优秀青年人才支持计划项目（gxyq2 018171）。

通讯作者: 潘献柱（1978.4-），男，硕士，副主任医师；研究方向：组织病理学。

引用本文:

解丹丹1 夏磊2 李松果1 潘献柱1. 前列腺癌组织中LncRNA LINC00355、miR-494-3p、CCND2的表达及临床意义[J]. 中国医药导报, 2022, 19(11): 123-126.
XIE Dandan1 XIA Lei2 LI Songguo1 PAN Xianzhu1. Expression and clinical significance of LncRNA LINC00355, miR-494-3p, and CCND2 mRNA in prostate cancer tissues#br#. 中国医药导报, 2022, 19(11): 123-126.

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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2022/V19/I11/123

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