1.The Second Department of Internal Medicine, Mingxiu Branch of International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530001, China;
2.Department of Spleen-stomach Liver Disease, International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530200, China;
3.Graduate School, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530001, China
Abstract：Objective To explore the clinical effect of Jianpi Yiwei Formula in the treatment of peptic ulcer with the syndrome of deficiency of spleen and stomach. Methods A total of 90 patients of peptic ulcer with the syndrome of deficiency of spleen and stomach who were treated in Department of Spleen-stomach Liver Disease in the International Zhuang Medical Hospital Affiliated to Guangxi University of Chinese Medicine from September 2019 to February 2021 were divided into the control group and the treatment group by random number table method, 45 cases in each group. The control group was given Omeprazole Enteric-coated Capsules. The treatment group was treated with Jianpi Yiwei Formula on the basis of the control group. The clinical efficacy was observed for four weeks. The changes situation of pepsinogen (PG)Ⅰ, PGⅡ, and the PGⅠ / PGⅡ before and after treatment, the adverse events in the two groups were observed and recorded. Results The clinical effect of the treatment group was better than that in the control group (P < 0.05). After treatment, PGⅠ in the two groups were lower than those before treatment, and the treatment group was lower than that in the control group (P ＜ 0.05). After treatment, PG Ⅱ in the treatment group was lower than that before treatment, and PGⅡ in the treatment group was lower than that in the control group (P ＜ 0.05). There were no adverse reactions such as rash, nausea and vomiting, and needlesickness in the both groups. Conclusion Jianpi Yiwei Formula can effectively inhibit the expression of PGⅠ and PGⅡ, and improve the function of gastrointestinal peristalsis, and has definite effect of peptic ulcer with the syndrome of deficiency of spleen and stomach, there is no adverse reaction, it is worthy of reference, promotion, and application in clinic.
蒋玉萍1 刘伟锋2 温智稀2 吴姗姗2 段桂姣3 吕艳杭3. 健脾益胃方治疗脾胃气虚型消化性溃疡的效果[J]. 中国医药导报, 2022, 19(10): 144-147,162.
JIANG Yuping1 LIU Weifeng2 WEN Zhixi2 WU Shanshan2 DUAN Guijiao3 LYU Yanhang3. Effect of Jianpi Yiwei Formula in the treatment of peptic ulcer with the syndrome of deficiency of spleen and stomach#br#. 中国医药导报, 2022, 19(10): 144-147,162.
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