Research progress of m6A modification in gastric cancer#br#
XIE Shengmao1 ZHANG Zhilong2 LI Chunhui3 SHI Fei4
1.Department of Gastroenterology, NO.969 Hospital, the Chinese People’s Liberation Army Joint Logistic Support Force, Inner Mongolia Autonomous Region, Hohhot 010051, China;
2.Department of General Surgery, NO.969 Hospital, the Chinese People’s Liberation Army Joint Logistic Support Force, Inner Mongolia Autonomous Region, Hohhot 010051, China;
3.Department of Respiratory and Critical Care Medicine, Inner Mongolia People’s Hospital, Inner Mongolia Autonomous Region, Hohhot 010010, China; 4.School of Medicine of Aeronautics and Astronautics, the Chinese People’s Liberation Army Air Force Medical University, Shaanxi Province, Xi’an 710032, China
Abstract：Gastric cancer is the most common gastrointestinal tumor in China, and its therapeutic effect is not good. More than 150 kinds of RNA modifications have been discovered, and the dynamic modification of m6A is the most abundant one in RNA modification. m6A modification plays an important role in RNA metabolism and is involved in many biological processes such as cell proliferation, differentiation, and apoptosis. m6A modification imbalance also plays an important role in the occurrence and development of gastric cancer, in-depth study of the molecular mechanism of gastric cancer can provide a new strategy for the treatment of gastric cancer.
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