Diagnostic efficiency of combined detection of brain natriuretic peptide, glucose, neuron-specific enolase and S-100β protein in severe hand, foot and mouth disease#br#
Abstract：Objective To explore the value of combined detection of brain natriuretic peptide (BNP), glucose (Glu), neuron-specific enolase (NSE), and S-100β protein (S-100β) in severe hand, foot and mouth disease. Methods A retrospective analysis was performed on the clinical data of 100 children hospitalized and diagnosed with hand, foot and mouth disease in the Department of Emergency, Hebei Children’s Hospital Affiliated to Hebei Medical University from May 2017 to May 2020, as well as 100 children who underwent physical examination during the same period. According to severity of the disease, the children with hand, foot and mouth disease were divided into mild group (41 cases) and severe group (59 cases), and the healthy children were taken as control group. The levels of BNP, Glu, NSE, and S-100β in three groups were compared, the influencing factors of severe hand, foot and mouth disease were analyzed by logistic regression, and the value of BNP, Glu, NSE, S-100β and the four indexes combined in the diagnosis of severe hand, foot and mouth disease were analyzed by ROC curve. Results The levels of BNP, Glu, NSE, and S-100β in severe group were higher than those in mild group and control group (P < 0.05); the levels of Glu and NSE in mild group were higher than those in control group (P < 0.05). BNP, Glu, NSE, and S-100β were the independent influencing factors of severe hand, foot and mouth disease (P < 0.05). The area under the curve of BNP, Glu, NSE, and S-100β and the four indicators combined to predict severe hand, foot and mouth disease were 0.815, 0.880, 0.639, 0.910, 0.914, and the sensitivity were 88.1%, 83.1%, 37.3%, 88.1%, 89.8%, the specificity were 61.0%, 87.8%, 95.1%, 90.2%, 90.2%. Conclusion The levels of BNP, Glu, NSE, and S-100β in children with severe hand, foot and mouth disease are significantly higher than those in mild children and healthy children. The combined examination of the four indicators is conducive to the early diagnosis of children with severe hand, foot and mouth disease.
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