Relationship between complement-C1q / tumor necrosis factor-related protein 5 and gestational diabetes mellitus#br#
XIN Yaping1 ZHU Yihan1 ZHANG Qi1 ZHANG Ke2 WANG Anying2
1.Department of Endocrinology, the Second Affiliated Hospital of Zhengzhou University, Henan Province, Zhengzhou 450000, China;
2.Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Zhengzhou University, Henan Province, Zhengzhou 450000, China
Abstract：Objective To study relationship between complement-C1q / tumor necrosis factor-related protein 5 (CTRP5) and gestational diabetes mellitus (GDM). Methods A total of 172 gravidas enrolled in the Second Affiliated Hospital of Zhengzhou University from June 2020 to June 2021 were divided into control group (80 gravidas) and GDM group (92 cases) according to whether they had GDM or not. Age, gestational age, pre-pregnancy body mass index (BMI), prenatal BMI, blood pressure, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), fasting blood glucose (FBG), glucose load 2 h blood glucose, fasting insulin (FINS), glycated hemoglobin (HbA1c), homeostasis model assessment-insulin resistance (HOMA-IR) index, CTRP5, and adipose triglyceride lipase (ATGL) were compared between the two groups. The correlation between CTRP5 and all indicators was analyzed, and the relationship between CTRP5 and GDM was analyzed by logistic regression model. Results Pre-pregnancy BMI, prenatal BMI, TC, TG, FBG, glucose load 2 h blood glucose, HbA1c, FINS, and HOMA-IR indexes in GDM group were all higher than those in control group, while ATGL and CTRP5 were all lower than those in control group, the differences were statistically significant (P ＜ 0.05). CTRP5 was negatively correlated with pre-pregnancy BMI, prenatal BMI, TC, TG, FBG, HbA1c, glucose load 2 h blood glucose, FINS, HOMA-IR index (r ＜ 0, P ＜ 0.05), and positively correlated with ATGL (r ＞ 0, P ＜ 0.05). Logistic regression model analysis showed that CTRP5 was still an independent influencing factor for the occurrence of GDM after adjusting pre-pregnancy BMI, prenatal BMI, TC, TG, FBG, HbA1c, glucose load 2 h blood glucose, FINS, and HOMA-IR index (P ＜ 0.05). Conclusion CTRP5 is an influential factor of GDM, which may be related to insulin resistance and glycolipid metabolism.
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