Research progress of Dexmedetomidine on organ protection by regulating autophagy#br#
WU Bei1 LI Yuebing2 WANG Weina2
1.The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310053, China;
2.Department of Anesthesiology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Province, Hangzhou 310005, China
Abstract：Organ diseases such as traumatic brain injury, ischemic stroke, myocardial ischemia-reperfusion injury, acute lung injury, acute kidney injury, etc., there is still no good treatment method, which seriously affects the prognosis of patients, and effective treatment methods are urgently needed. Autophagy is very important in maintaining the homeostasis of the structure and function of brain, heart, lung, kidney, and other organs. The imbalance of autophagy will lead to the occurrence and development of a variety of organ diseases. A large number of studies have proved that Dexmedetomidine may play an organ protective role by regulating autophagy activity. This paper reviews the regulatory effect of Dexmedetomidine on autophagy in nervous system diseases, heart diseases, lung diseases, and other organ diseases, which opens up a new idea for the treatment of organ diseases.
吴蓓1 李跃兵2 王维娜2. 右美托咪定通过调节自噬对器官保护的研究进展[J]. 中国医药导报, 2022, 19(9): 41-45.
WU Bei1 LI Yuebing2 WANG Weina2. Research progress of Dexmedetomidine on organ protection by regulating autophagy#br#. 中国医药导报, 2022, 19(9): 41-45.
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