Discussion on medication rules of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome#br#
DU Juan1 LI Ziran2 YE Yan2
1.Department of Pulmonary Diseases, Guangzhou Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510130, China;
2.Department of Pulmonary Diseases, the Affiliated TCM Hospital of Guangzhou Medical University, Guangdong Province, Guangzhou 510130, China
Abstract：Objective To explore the medication rules of Chinese medicine of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome. Methods The subject words were “acute exacerbation of chronic obstructive pulmonary disease” or “AECOPD” and “phlegm heat”. The literatures included in CNKI, Wanfang and VIP database from January 2010 to June 2021 were searched and prescription database was established. Excel 2019, SPSS Modeler 18.0, and SPSS Statistics 26.0 softwares were used to analyze frequency, efficacy, meridian tropism, related drug pairs, and clustering prescription. Results A total of 126 articles and 128 prescriptions were counted, including 178 herbs. The top five high frequency drugs were Scutellariae Radix, Armeniacae Semen Amarum, Pinelliae Rhizoma Praeparatum, Glycyrrhizae Radix et Rhizoma, Mori Cortex. It was mainly used for clearing heat and resolving phlegm, relieving cough and relieving asthma. The taste of medicine was mainly bitter, sweet and pungent, and its properties were mainly cold, warm and flat, and its meridians were mainly in lung, stomach, liver and spleen, and so on. The drug pairs with the highest correlation were Perillae Fructus and Mori Cortex. Five kinds of drugs were classified by cluster analysis. Conclusion Clearing heat and resolving phlegm, relieving cough and relieving asthma are the core treatment principles of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome. Drugs for regulating qi, removing dampness, promoting blood circulation and diarrhea are matched with the syndrome.
杜娟1 里自然2 叶焰2. 慢性阻塞性肺疾病急性加重期痰热壅肺证的用药规律探讨[J]. 中国医药导报, 2022, 19(8): 143-146,168.
DU Juan1 LI Ziran2 YE Yan2. Discussion on medication rules of acute exacerbation of chronic obstructive pulmonary disease with phlegm-heat obstructing lung syndrome#br#. 中国医药导报, 2022, 19(8): 143-146,168.
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